C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: bone morphogenetic protein 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000378827 BMP2-001 ENSG00000125845 9606 + 20:6767664-6780280 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000378827
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000378827 2.590±0.00 2.378±0.00 0.347±0.00 1.437±0.93 2.784±1.97 2.353±0.10 0.655±0.38 1.654±1.15 1.289±0.29 5.451±3.77 0.516±0.07 0.826±0.51 7.120±5.13 0.909±0.57

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001J1 CIL_0001J1_0001 CGP 20:6074845-6780280
CIL_0002W0 CIL_0002W0_0001 CGP 20:6767664-7940474

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000187 IDA activation of MAPK activity
GO:0001501 TAS skeletal system development
GO:0001649 IDA osteoblast differentiation
GO:0001658 ISS branching involved in ureteric bud morphogenesis
GO:0001666 ISS response to hypoxia
GO:0001701 ISS in utero embryonic development
GO:0001837 IDA epithelial to mesenchymal transition
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0001938 IDA positive regulation of endothelial cell proliferation
GO:0002062 IDA chondrocyte differentiation
GO:0003130 IDA BMP signaling pathway involved in heart induction
GO:0003181 ISS atrioventricular valve morphogenesis
GO:0003203 ISS endocardial cushion morphogenesis
GO:0003308 IDA negative regulation of Wnt signaling pathway involved in heart development
GO:0004745 ISS retinol dehydrogenase activity
GO:0005102 TAS receptor binding
GO:0005125 IEA cytokine activity
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005615 IEA extracellular space
GO:0006029 IEA proteoglycan metabolic process
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006468 IDA protein phosphorylation
GO:0006954 ISS inflammatory response
GO:0007219 ISS Notch signaling pathway
GO:0007267 TAS cell-cell signaling
GO:0007507 ISS heart development
GO:0008083 IEA growth factor activity
GO:0008285 IDA negative regulation of cell proliferation
GO:0009790 ISS embryo development
GO:0009887 ISS organ morphogenesis
GO:0009986 IDA cell surface
GO:0010628 IDA positive regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0010718 IDA positive regulation of epithelial to mesenchymal transition
GO:0010862 IDA positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010894 IDA negative regulation of steroid biosynthetic process
GO:0010922 IDA positive regulation of phosphatase activity
GO:0019211 IDA phosphatase activator activity
GO:0021537 IDA telencephalon development
GO:0021978 ISS telencephalon regionalization
GO:0030177 ISS positive regulation of Wnt signaling pathway
GO:0030198 TAS extracellular matrix organization
GO:0030282 ISS bone mineralization
GO:0030335 ISS positive regulation of cell migration
GO:0030501 IDA positive regulation of bone mineralization
GO:0030509 IDA BMP signaling pathway
GO:0031648 IEA protein destabilization
GO:0032348 IDA negative regulation of aldosterone biosynthetic process
GO:0033690 ISS positive regulation of osteoblast proliferation
GO:0035051 IDA cardiocyte differentiation
GO:0035054 ISS embryonic heart tube anterior/posterior pattern specification
GO:0035630 IDA bone mineralization involved in bone maturation
GO:0040007 IEA growth
GO:0042475 ISS odontogenesis of dentin-containing tooth
GO:0042482 ISS positive regulation of odontogenesis
GO:0042487 IEA regulation of odontogenesis of dentin-containing tooth
GO:0043065 IDA positive regulation of apoptotic process
GO:0043410 IDA positive regulation of MAPK cascade
GO:0043569 IDA negative regulation of insulin-like growth factor receptor signaling pathway
GO:0045165 ISS cell fate commitment
GO:0045597 IEA positive regulation of cell differentiation
GO:0045600 ISS positive regulation of fat cell differentiation
GO:0045666 ISS positive regulation of neuron differentiation
GO:0045669 IDA positive regulation of osteoblast differentiation
GO:0045778 IDA positive regulation of ossification
GO:0045786 IDA negative regulation of cell cycle
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046332 IDA SMAD binding
GO:0046982 IDA protein heterodimerization activity
GO:0048711 ISS positive regulation of astrocyte differentiation
GO:0048762 IDA mesenchymal cell differentiation
GO:0048839 ISS inner ear development
GO:0051042 IDA negative regulation of calcium-independent cell-cell adhesion
GO:0055007 IMP cardiac muscle cell differentiation
GO:0055008 ISS cardiac muscle tissue morphogenesis
GO:0055114 IEA oxidation-reduction process
GO:0060039 ISS pericardium development
GO:0060128 ISS corticotropin hormone secreting cell differentiation
GO:0060129 ISS thyroid-stimulating hormone-secreting cell differentiation
GO:0060317 IDA cardiac epithelial to mesenchymal transition
GO:0060389 IDA pathway-restricted SMAD protein phosphorylation
GO:0060395 IDA SMAD protein signal transduction
GO:0060485 IMP mesenchyme development
GO:0060804 ISS positive regulation of Wnt signaling pathway by BMP signaling pathway
GO:0061036 IDA positive regulation of cartilage development
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0070700 IDA BMP receptor binding
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071407 IEA cellular response to organic cyclic compound
GO:0071773 IDA cellular response to BMP stimulus
GO:0072138 ISS mesenchymal cell proliferation involved in ureteric bud development
GO:0090090 IEP negative regulation of canonical Wnt signaling pathway
GO:1900745 IDA positive regulation of p38MAPK cascade
GO:1901522 IDA positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:2000065 IDA negative regulation of cortisol biosynthetic process
GO:2000726 IDA negative regulation of cardiac muscle cell differentiation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000028836 Bmp2-001 protein_coding Mus_musculus 0 2841

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