C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: glutamate-cysteine ligase, modifier subunit
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000029769 Gclm-001 ENSMUSG00000028124 10090 + 3:122245557-122269984 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000029769
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000029769 3.491±0.87 13.523±2.48 8.519±0.01 3.164±0.49 5.371±3.37 7.161±1.09 1.263±0.32 21.560±6.54 20.752±4.67 6.276±2.10 1.231±0.50 8.201±4.14 4.916±3.37 2.067±1.12

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009DI CIL_0009DI_0002 VISTA 3:121653542-122254391
CIL_0009DJ CIL_0009DJ_0002 VISTA 3:121747471-122349247
CIL_0009DH CIL_0009DH_0002 VISTA 3:121992915-122594267
CIL_00005U CIL_00005U_0002 CGP 3:122245557-122285269

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004357 ISS glutamate-cysteine ligase activity
GO:0006534 IMP cysteine metabolic process
GO:0006536 ISS glutamate metabolic process
GO:0006749 IMP glutathione metabolic process
GO:0006750 ISS glutathione biosynthetic process
GO:0006979 ISS response to oxidative stress
GO:0008637 IGI apoptotic mitochondrial changes
GO:0017109 IDA glutamate-cysteine ligase complex
GO:0035226 ISS glutamate-cysteine ligase catalytic subunit binding
GO:0035229 IDA positive regulation of glutamate-cysteine ligase activity
GO:0042493 ISS response to drug
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0046982 IPI protein heterodimerization activity
GO:0050880 ISS regulation of blood vessel size
GO:0051409 IEA response to nitrosative stress
GO:0051900 IGI regulation of mitochondrial depolarization
GO:2001237 IGI negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000370238 GCLM-001 protein_coding Homo_sapiens 0 1190
ENST00000462183 GCLM-003 processed_transcript Homo_sapiens 3e-16 90
ENST00000467772 GCLM-002 processed_transcript Homo_sapiens 0 726
ENST00000615724 GCLM-201 protein_coding Homo_sapiens 0 859
ENST00000619076 GCLM-202 protein_coding Homo_sapiens 0 652

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