C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: low density lipoprotein receptor
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000034713 Ldlr-201 ENSMUSG00000032193 10090 + 9:21723576-21749916 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000034713
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000034713 14.626±1.99 62.610±15.90 14.008±2.65 6.843±0.90 19.336±8.11 65.838±5.64 2.617±0.77 11.957±0.85 33.062±19.63 40.476±3.15 2.184±0.34 30.184±6.41 41.685±24.25 0.888±0.33

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00058P CIL_00058P_0004 CGP 9:21616169-21749916
CIL_000169 CIL_000169_0002 CGP 9:21723576-21760286

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001948 IEA glycoprotein binding
GO:0005041 IDA low-density lipoprotein receptor activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005764 ISS lysosome
GO:0005768 IDA endosome
GO:0005769 ISS early endosome
GO:0005770 ISS late endosome
GO:0005794 ISS Golgi apparatus
GO:0005886 TAS plasma membrane
GO:0005905 IEA coated pit
GO:0006629 IGI lipid metabolic process
GO:0006898 IDA receptor-mediated endocytosis
GO:0008203 IMP cholesterol metabolic process
GO:0009897 IEA external side of plasma membrane
GO:0009986 ISS cell surface
GO:0010867 IMP positive regulation of triglyceride biosynthetic process
GO:0010899 IMP regulation of phosphatidylcholine catabolic process
GO:0015914 IMP phospholipid transport
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0030169 IDA low-density lipoprotein particle binding
GO:0030229 IDA very-low-density lipoprotein particle receptor activity
GO:0030299 IEA intestinal cholesterol absorption
GO:0030301 IMP cholesterol transport
GO:0034362 IEA low-density lipoprotein particle
GO:0034383 IMP low-density lipoprotein particle clearance
GO:0042157 IGI lipoprotein metabolic process
GO:0042159 IDA lipoprotein catabolic process
GO:0042632 IGI cholesterol homeostasis
GO:0043235 ISO receptor complex
GO:0070508 IMP cholesterol import
GO:2000188 IMP regulation of cholesterol homeostasis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000252444 LDLR-004 protein_coding Homo_sapiens 0 1890
ENST00000557933 LDLR-012 protein_coding Homo_sapiens 0 1711
ENST00000558013 LDLR-002 protein_coding Homo_sapiens 0 1857
ENST00000558518 LDLR-003 protein_coding Homo_sapiens 0 1890

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