C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: heart and neural crest derivatives expressed transcript 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000040104 Hand2-001 ENSMUSG00000038193 10090 + 8:57320983-57324517 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000040104
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000040104 7.246±7.23 22.866±6.77 19.024±0.82 0.086±0.06 0.023±0.01 4.919±1.80 5.864±1.78 0.134±0.06 1.883±0.32 0.124±0.03 0.053±0.02 2.334±0.91 7.949±4.12 0.140±0.20

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00080O CIL_00080O_0002 VISTA 8:56891052-57495815
CIL_0008BZ CIL_0008BZ_0002 VISTA 8:57035224-57635792
CIL_0008VG CIL_0008VG_0002 VISTA 8:57047180-57651136

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000790 IEA nuclear chromatin
GO:0000977 IEA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001525 IEA angiogenesis
GO:0001701 IMP in utero embryonic development
GO:0001947 IMP heart looping
GO:0001967 IMP suckling behavior
GO:0003007 IMP heart morphogenesis
GO:0003219 IMP cardiac right ventricle formation
GO:0003253 IMP cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0003266 IMP regulation of secondary heart field cardioblast proliferation
GO:0003278 IMP apoptotic process involved in heart morphogenesis
GO:0003680 IEA AT DNA binding
GO:0003713 ISS transcription coactivator activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IDA transcription factor complex
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0007507 IGI heart development
GO:0007512 IMP adult heart development
GO:0008134 IPI transcription factor binding
GO:0010463 IMP mesenchymal cell proliferation
GO:0010667 IMP negative regulation of cardiac muscle cell apoptotic process
GO:0014032 IMP neural crest cell development
GO:0033613 ISS activating transcription factor binding
GO:0042475 IGI odontogenesis of dentin-containing tooth
GO:0042733 IDA embryonic digit morphogenesis
GO:0042803 IPI protein homodimerization activity
GO:0043066 IMP negative regulation of apoptotic process
GO:0043234 IEA protein complex
GO:0043392 IDA negative regulation of DNA binding
GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IGI sequence-specific DNA binding
GO:0043586 IMP tongue development
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045668 IDA negative regulation of osteoblast differentiation
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IPI protein heterodimerization activity
GO:0048485 IDA sympathetic nervous system development
GO:0048538 IMP thymus development
GO:0048935 IDA peripheral nervous system neuron development
GO:0060021 IMP palate development
GO:0060485 IGI mesenchyme development
GO:0060536 IGI cartilage morphogenesis
GO:0060982 IMP coronary artery morphogenesis
GO:0061032 IMP visceral serous pericardium development
GO:0061309 IMP cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061325 IMP cell proliferation involved in outflow tract morphogenesis
GO:0061371 IMP determination of heart left/right asymmetry
GO:0070888 IDA E-box binding
GO:2000679 IEA positive regulation of transcription regulatory region DNA binding
GO:2000763 IMP positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process
GO:2000764 IMP positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000020409 hand2-001 protein_coding Danio_rerio 0 263
ENST00000359562 HAND2-001 protein_coding Homo_sapiens 0 2350
ENST00000503024 HAND2-006 nonsense_mediated_decay Homo_sapiens 0 628
ENST00000505300 HAND2-003 processed_transcript Homo_sapiens 0 922
ENST00000621866 HAND2-201 protein_coding Homo_sapiens 0 1194

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