C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000053413 Cdk5r1-001 ENSMUSG00000048895 10090 + 11:80477023-80481184 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000053413
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000053413 0.516±0.11 1.238±0.31 0.310±0.24 107.891±49.86 0.807±0.20 0.490±0.12 0.297±0.00 0.151±0.09 0.336±0.25 0.421±0.14 0.097±0.03 2.092±0.81 1.146±0.56 0.476±0.11

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005RM CIL_0005RM_0004 CGP 11:80428615-80481184
CIL_0005RL CIL_0005RL_0003 CGP 11:80477023-80780025

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001764 IGI neuron migration
GO:0004693 IEA cyclin-dependent protein serine/threonine kinase activity
GO:0005509 ISS calcium ion binding
GO:0005515 IPI protein binding
GO:0005634 IDA:ISS nucleus
GO:0005737 IDA:ISS cytoplasm
GO:0005886 IEA plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007158 IMP neuron cell-cell adhesion
GO:0007213 ISS G-protein coupled acetylcholine receptor signaling pathway
GO:0007411 IMP axon guidance
GO:0007413 IMP axonal fasciculation
GO:0007420 IMP brain development
GO:0008092 TAS cytoskeletal protein binding
GO:0009790 ISS embryo development
GO:0014069 ISS postsynaptic density
GO:0016020 ISS membrane
GO:0016301 ISS kinase activity
GO:0016533 IEA cyclin-dependent protein kinase 5 holoenzyme complex
GO:0016534 IMP cyclin-dependent protein kinase 5 activator activity
GO:0018105 IEA peptidyl-serine phosphorylation
GO:0018107 IEA peptidyl-threonine phosphorylation
GO:0019901 IEA protein kinase binding
GO:0021549 IMP cerebellum development
GO:0021722 IGI superior olivary nucleus maturation
GO:0021766 IGI hippocampus development
GO:0021799 IMP cerebral cortex radially oriented cell migration
GO:0021819 IGI layer formation in cerebral cortex
GO:0030182 ISS neuron differentiation
GO:0030424 ISS axon
GO:0030425 ISS dendrite
GO:0030426 ISS growth cone
GO:0030517 IGI negative regulation of axon extension
GO:0031175 ISS neuron projection development
GO:0031594 ISS neuromuscular junction
GO:0032956 IMP regulation of actin cytoskeleton organization
GO:0033136 IDA serine phosphorylation of STAT3 protein
GO:0035235 ISS ionotropic glutamate receptor signaling pathway
GO:0043025 ISS neuronal cell body
GO:0043197 ISS dendritic spine
GO:0043292 ISS contractile fiber
GO:0043525 ISS positive regulation of neuron apoptotic process
GO:0043539 ISS protein serine/threonine kinase activator activity
GO:0045296 ISS cadherin binding
GO:0045860 IGI positive regulation of protein kinase activity
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0046875 IEA ephrin receptor binding
GO:0048013 IMP ephrin receptor signaling pathway
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048511 IEA rhythmic process
GO:0051726 IEA regulation of cell cycle
GO:0061001 IMP regulation of dendritic spine morphogenesis
GO:0070507 IMP regulation of microtubule cytoskeleton organization
GO:0071158 IMP positive regulation of cell cycle arrest
GO:0090314 IDA positive regulation of protein targeting to membrane

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000313401 CDK5R1-001 protein_coding Homo_sapiens 0 1613
ENST00000584716 CDK5R1-002 nonsense_mediated_decay Homo_sapiens 0 399
ENST00000584792 CDK5R1-003 protein_coding Homo_sapiens 0 440

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