C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000313401 CDK5R1-001 ENSG00000176749 9606 + 17:32486619-32491256 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverMuscleOvaryPlacentaTestisENST00000313401
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Muscle Ovary Placenta Testis
ENST00000313401 0.207±0.00 1.912±0.00 23.275±13.28 0.207±0.16 0.110±0.00 0.031±0.00 0.496±0.00 0.044±0.00 0.013±0.00 0.768±0.45 0.402±0.09 2.633±0.03

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005RM CIL_0005RM_0003 CGP 17:32444261-32491256
CIL_0005RL CIL_0005RL_0002 CGP 17:32486619-32877177

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000079 TAS regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001764 ISS neuron migration
GO:0004672 TAS protein kinase activity
GO:0004693 IEA cyclin-dependent protein serine/threonine kinase activity
GO:0005509 ISS calcium ion binding
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007158 ISS neuron cell-cell adhesion
GO:0007213 ISS G-protein coupled acetylcholine receptor signaling pathway
GO:0007411 ISS axon guidance
GO:0007413 ISS axonal fasciculation
GO:0007420 ISS brain development
GO:0008283 TAS cell proliferation
GO:0009790 IEA embryo development
GO:0014069 ISS postsynaptic density
GO:0016020 ISS membrane
GO:0016301 ISS kinase activity
GO:0016533 IEA cyclin-dependent protein kinase 5 holoenzyme complex
GO:0016534 IEA cyclin-dependent protein kinase 5 activator activity
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0019901 IPI protein kinase binding
GO:0021549 IEA cerebellum development
GO:0021722 IEA superior olivary nucleus maturation
GO:0021766 IEA hippocampus development
GO:0021799 IEA cerebral cortex radially oriented cell migration
GO:0021819 IEA layer formation in cerebral cortex
GO:0030182 ISS neuron differentiation
GO:0030424 ISS axon
GO:0030425 ISS dendrite
GO:0030426 ISS growth cone
GO:0030517 IEA negative regulation of axon extension
GO:0031175 ISS neuron projection development
GO:0031594 ISS neuromuscular junction
GO:0032956 IEA regulation of actin cytoskeleton organization
GO:0033136 IEA serine phosphorylation of STAT3 protein
GO:0035235 ISS ionotropic glutamate receptor signaling pathway
GO:0043025 ISS neuronal cell body
GO:0043197 ISS dendritic spine
GO:0043292 ISS contractile fiber
GO:0043525 ISS positive regulation of neuron apoptotic process
GO:0043539 ISS protein serine/threonine kinase activator activity
GO:0045296 ISS cadherin binding
GO:0045664 NAS regulation of neuron differentiation
GO:0045860 IEA positive regulation of protein kinase activity
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0046875 IEA ephrin receptor binding
GO:0048013 ISS ephrin receptor signaling pathway
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048511 IEA rhythmic process
GO:0051726 IEA regulation of cell cycle
GO:0061001 ISS regulation of dendritic spine morphogenesis
GO:0070507 IEA regulation of microtubule cytoskeleton organization
GO:0071158 IEA positive regulation of cell cycle arrest
GO:0090314 IEA positive regulation of protein targeting to membrane

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000053413 Cdk5r1-001 protein_coding Mus_musculus 0 1613
ENSMUST00000147694 Cdk5r1-002 protein_coding Mus_musculus 0 664
ENSMUST00000160379 Cdk5r2-001 protein_coding Mus_musculus 0 265
ENSDART00000055262 cdk5r1a-001 protein_coding Danio_rerio 0 265
ENSDART00000052420 protein_coding Danio_rerio 0 228

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