C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: forkhead box O1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000053764 Foxo1-001 ENSMUSG00000044167 10090 + 3:52268337-52350109 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000053764
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000053764 19.123±0.39 8.586±1.20 7.533±1.01 2.656±0.34 17.862±1.90 6.345±0.56 5.828±0.41 9.913±0.56 3.322±1.34 12.891±0.62 3.105±0.74 51.075±10.28 3.086±1.77 1.375±0.60

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00087B CIL_00087B_0002 VISTA 3:52101126-52702130

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000989 IPI transcription factor binding transcription factor activity
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001227 IGI RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001568 IMP blood vessel development
GO:0003677 IDA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 ISS cytoplasm
GO:0005829 TAS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006914 IEA autophagy
GO:0006915 IEA apoptotic process
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0008286 IMP insulin receptor signaling pathway
GO:0009267 ISS cellular response to starvation
GO:0010508 ISS positive regulation of autophagy
GO:0031018 TAS endocrine pancreas development
GO:0031625 IEA ubiquitin protein ligase binding
GO:0032869 IDA cellular response to insulin stimulus
GO:0032873 IEA negative regulation of stress-activated MAPK cascade
GO:0034599 IDA cellular response to oxidative stress
GO:0035947 IMP regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
GO:0042127 IMP regulation of cell proliferation
GO:0042593 IDA glucose homeostasis
GO:0043065 ISS positive regulation of apoptotic process
GO:0043066 ISS negative regulation of apoptotic process
GO:0043565 ISS sequence-specific DNA binding
GO:0045599 ISS negative regulation of fat cell differentiation
GO:0045722 IMP positive regulation of gluconeogenesis
GO:0045732 ISS positive regulation of protein catabolic process
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0051721 IDA protein phosphatase 2A binding
GO:0071455 ISS cellular response to hyperoxia
GO:0071732 IDA cellular response to nitric oxide
GO:0090090 IGI negative regulation of canonical Wnt signaling pathway
GO:0097150 IGI neuronal stem cell maintenance
GO:2000177 IGI regulation of neural precursor cell proliferation
GO:2000377 IGI regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000087898 foxo1b-001 protein_coding Danio_rerio 0 320
ENST00000343882 FOXO3-001 protein_coding Homo_sapiens 0 278
ENST00000379561 FOXO1-001 protein_coding Homo_sapiens 0 3544
ENST00000406360 FOXO3-201 protein_coding Homo_sapiens 0 278
ENST00000473775 FOXO1-002 processed_transcript Homo_sapiens 1e-35 152
ENST00000504678 FOXO1B-001 processed_pseudogene Homo_sapiens 0 1138

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