C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: SMAD specific E3 ubiquitin protein ligase 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000085684 Smurf1-001 ENSMUSG00000038780 10090 - 5:144876502-144965847 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000085684
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000085684 13.521±2.88 7.185±1.71 8.685±1.14 9.973±3.57 14.938±3.12 9.798±0.93 6.159±1.44 5.346±1.02 1.769±0.91 13.301±2.34 2.536±0.67 15.368±4.59 6.519±3.39 6.143±2.43

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004TP CIL_0004TP_0002 CGP 5:144768092-144965847
CIL_0004TQ CIL_0004TQ_0002 CGP 5:144876495-145084030

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000209 ISS protein polyubiquitination
GO:0004842 ISS ubiquitin-protein transferase activity
GO:0005634 IBA nucleus
GO:0005737 ISS cytoplasm
GO:0005886 IEA plasma membrane
GO:0006611 IEA protein export from nucleus
GO:0007179 IBA transforming growth factor beta receptor signaling pathway
GO:0016567 IMP protein ubiquitination
GO:0016874 IEA ligase activity
GO:0030154 ISS cell differentiation
GO:0030279 IMP negative regulation of ossification
GO:0030424 IEA axon
GO:0030509 ISS BMP signaling pathway
GO:0030512 IEA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030579 IEA ubiquitin-dependent SMAD protein catabolic process
GO:0032801 IEA receptor catabolic process
GO:0034394 IEA protein localization to cell surface
GO:0042787 ISS protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043025 IEA neuronal cell body
GO:0043161 IEA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070062 IEA extracellular vesicular exosome
GO:0070411 IEA I-SMAD binding
GO:0070412 IEA R-SMAD binding

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000361125 SMURF1-001 protein_coding Homo_sapiens 0 1807
ENST00000361368 SMURF1-002 protein_coding Homo_sapiens 0 2935
ENST00000472627 SMURF1-003 processed_transcript Homo_sapiens 0 499
ENST00000480055 SMURF1-004 processed_transcript Homo_sapiens 0 791

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