C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: dedicator of cytokinesis 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000280333 DOCK1-001 ENSG00000150760 9606 + 10:126905409-127452517 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000280333
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000280333 14.514±0.00 3.915±0.00 1.984±0.00 5.602±4.49 5.975±4.43 7.047±5.72 4.532±0.00 5.509±5.15 1.217±0.15 5.508±0.00 0.696±0.55 9.059±4.87 7.470±0.24 6.484±4.16

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00047A CIL_00047A_0002 CGP 10:126424997-127452517
CIL_00047B CIL_00047B_0002 CGP 10:126905409-127452517

Gene Ontology

GO IDEvidence TypeGO Description
GO:0002244 IEA hematopoietic progenitor cell differentiation
GO:0005085 IEA guanyl-nucleotide exchange factor activity
GO:0005096 TAS GTPase activator activity
GO:0005488 IEA binding
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006911 TAS phagocytosis, engulfment
GO:0006915 IEA apoptotic process
GO:0007165 TAS signal transduction
GO:0007229 TAS integrin-mediated signaling pathway
GO:0007264 IEA small GTPase mediated signal transduction
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0009055 IEA electron carrier activity
GO:0016020 IEA membrane
GO:0016477 IEA cell migration
GO:0017124 IEA SH3 domain binding
GO:0020037 IEA heme binding
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043547 IEA positive regulation of GTPase activity
GO:0045087 TAS innate immune response

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000084488 Dock1-201 protein_coding Mus_musculus 0 6499
ENSMUST00000154178 Dock2-006 retained_intron Mus_musculus 3e-31 143
ENSMUST00000101365 Dock2-002 protein_coding Mus_musculus 3e-31 143
ENSMUST00000093193 Dock2-001 protein_coding Mus_musculus 3e-31 143
ENSMUST00000143540 Dock2-005 nonsense_mediated_decay Mus_musculus 9e-21 108

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