C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: cyclin-dependent kinase inhibitor 2A
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000107131 Cdkn2a-002 ENSMUSG00000044303 10090 - 4:89274541-89294653 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000107131
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000107131 0.472±0.08 1.650±0.51 0.394±0.00 0.058±0.02 0.596±0.12 0.289±0.06 0.142±0.08 0.083±0.08 0.041±0.01 0.449±0.06 0.089±0.00 0.922±0.48 11.499±7.93 4.476±1.81

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007YE CIL_0007YE_0002 VISTA 4:89088208-89693783
CIL_0007U7 CIL_0007U7_0002 VISTA 4:89092538-89696083
CIL_0007YH CIL_0007YH_0002 VISTA 4:89093251-89700067
CIL_0007YG CIL_0007YG_0002 VISTA 4:89099831-89706701
CIL_0007U8 CIL_0007U8_0002 VISTA 4:89105459-89706480
CIL_00095D CIL_00095D_0002 VISTA 4:89105812-89710925
CIL_000945 CIL_000945_0002 VISTA 4:89116711-89721138
CIL_0008WE CIL_0008WE_0002 VISTA 4:89121046-89725353
CIL_0007YC CIL_0007YC_0002 VISTA 4:89125337-89732294
CIL_0008P9 CIL_0008P9_0002 VISTA 4:89126411-89729104
CIL_00099P CIL_00099P_0002 VISTA 4:89127311-89729167
CIL_00099O CIL_00099O_0002 VISTA 4:89131159-89734211
CIL_0008TL CIL_0008TL_0002 VISTA 4:89131716-89739478
CIL_00094Y CIL_00094Y_0002 VISTA 4:89144756-89747133
CIL_0008SY CIL_0008SY_0002 VISTA 4:89146082-89752900
CIL_0008T0 CIL_0008T0_0002 VISTA 4:89152132-89755541
CIL_00085X CIL_00085X_0002 VISTA 4:89155335-89760083
CIL_00094Z CIL_00094Z_0002 VISTA 4:89157896-89760037
CIL_0008GG CIL_0008GG_0002 VISTA 4:89168919-89771433

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000079 IDA regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000209 ISS protein polyubiquitination
GO:0001652 IDA granular component
GO:0003677 IEA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0004861 IDA cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 IPI protein binding
GO:0005654 IDA nucleoplasm
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0005739 IEA mitochondrion
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006364 IEA rRNA processing
GO:0006915 IEA apoptotic process
GO:0007050 IDA cell cycle arrest
GO:0007568 IMP aging
GO:0007569 IDA cell aging
GO:0008544 IMP epidermis development
GO:0009303 IGI rRNA transcription
GO:0010468 IMP regulation of gene expression
GO:0030308 IMP negative regulation of cell growth
GO:0030889 IMP negative regulation of B cell proliferation
GO:0031647 IMP regulation of protein stability
GO:0033088 IMP negative regulation of immature T cell proliferation in thymus
GO:0033600 IMP negative regulation of mammary gland epithelial cell proliferation
GO:0035019 IGI somatic stem cell maintenance
GO:0042593 IMP glucose homeostasis
GO:0043517 IC positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045736 IDA negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045786 IDA negative regulation of cell cycle
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0046822 IGI regulation of nucleocytoplasmic transport
GO:0048103 IMP somatic stem cell division
GO:0051091 IMP positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051444 IDA negative regulation of ubiquitin-protein transferase activity
GO:0055105 IDA ubiquitin-protein transferase inhibitor activity
GO:0060058 IMP positive regulation of apoptotic process involved in mammary gland involution
GO:0070301 IDA cellular response to hydrogen peroxide
GO:0070534 ISS protein K63-linked ubiquitination
GO:0090398 IDA cellular senescence

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000276925 CDKN2B-001 protein_coding Homo_sapiens 9e-39 167
ENST00000304494 CDKN2A-001 protein_coding Homo_sapiens 2e-35 154
ENST00000361570 CDKN2A-201 protein_coding Homo_sapiens 5e-36 156
ENST00000380142 CDKN2B-002 protein_coding Homo_sapiens 2e-38 163
ENST00000380150 CDKN2A-011 processed_transcript Homo_sapiens 3e-35 152
ENST00000380151 CDKN2A-003 nonsense_mediated_decay Homo_sapiens 2e-33 147
ENST00000479692 CDKN2A-008 protein_coding Homo_sapiens 2e-33 147
ENST00000494262 CDKN2A-005 protein_coding Homo_sapiens 3e-33 147
ENST00000497750 CDKN2A-010 protein_coding Homo_sapiens 4e-34 148
ENST00000498124 CDKN2A-009 protein_coding Homo_sapiens 1e-35 154
ENST00000498628 CDKN2A-006 protein_coding Homo_sapiens 7e-34 148
ENST00000530628 CDKN2A-013 protein_coding Homo_sapiens 1e-36 158
ENST00000578845 CDKN2A-015 protein_coding Homo_sapiens 4e-35 152
ENST00000579122 CDKN2A-014 protein_coding Homo_sapiens 1e-35 154
ENST00000579591 CDKN2B-003 retained_intron Homo_sapiens 8e-39 165
ENST00000579755 CDKN2A-004 protein_coding Homo_sapiens 2e-36 158

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