C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: GLI-Kruppel family member GLI3
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000110510 Gli3-001 ENSMUSG00000021318 10090 + 13:15463980-15730026 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000110510
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000110510 2.285±1.12 0.878±0.37 2.172±0.47 1.370±0.94 0.943±0.27 0.892±0.25 0.337±0.01 0.188±0.09 0.113±0.07 0.757±0.36 0.145±0.04 1.437±0.61 0.354±0.20 0.218±0.14

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008FY CIL_0008FY_0002 VISTA 13:15001053-15602135
CIL_0009D0 CIL_0009D0_0002 VISTA 13:15185450-15787168
CIL_0008NK CIL_0008NK_0002 VISTA 13:15243030-15845007
CIL_0007V6 CIL_0007V6_0002 VISTA 13:15248974-15850833
CIL_0008OL CIL_0008OL_0002 VISTA 13:15364354-15965305

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001656 IGI metanephros development
GO:0001658 IGI branching involved in ureteric bud morphogenesis
GO:0001701 IMP in utero embryonic development
GO:0001822 IGI kidney development
GO:0002052 IMP positive regulation of neuroblast proliferation
GO:0003682 IGI chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 IEA cytosol
GO:0005929 ISO cilium
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IMP regulation of transcription, DNA-templated
GO:0007224 IGI smoothened signaling pathway
GO:0007389 IGI pattern specification process
GO:0007411 IMP axon guidance
GO:0007417 IGI central nervous system development
GO:0007420 IMP brain development
GO:0007442 IGI hindgut morphogenesis
GO:0007507 IGI heart development
GO:0008013 IEA beta-catenin binding
GO:0008285 IGI negative regulation of cell proliferation
GO:0009952 IMP anterior/posterior pattern specification
GO:0009953 IMP dorsal/ventral pattern formation
GO:0009954 IGI proximal/distal pattern formation
GO:0010468 IGI regulation of gene expression
GO:0016485 IDA protein processing
GO:0016592 IEA mediator complex
GO:0016607 IDA nuclear speck
GO:0017053 IDA transcriptional repressor complex
GO:0021513 IGI spinal cord dorsal/ventral patterning
GO:0021522 IGI spinal cord motor neuron differentiation
GO:0021537 IMP telencephalon development
GO:0021543 IMP pallium development
GO:0021544 IMP subpallium development
GO:0021631 IMP optic nerve morphogenesis
GO:0021766 IMP hippocampus development
GO:0021775 IGI smoothened signaling pathway involved in ventral spinal cord interneuron specification
GO:0021776 IGI smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
GO:0021798 IMP forebrain dorsal/ventral pattern formation
GO:0021801 IMP cerebral cortex radial glia guided migration
GO:0021861 IMP forebrain radial glial cell differentiation
GO:0021915 IMP neural tube development
GO:0022018 IMP lateral ganglionic eminence cell proliferation
GO:0030318 IMP melanocyte differentiation
GO:0030324 IGI lung development
GO:0030326 IMP embryonic limb morphogenesis
GO:0030879 IMP mammary gland development
GO:0030900 IMP forebrain development
GO:0032332 IMP positive regulation of chondrocyte differentiation
GO:0033077 IMP T cell differentiation in thymus
GO:0035035 IEA histone acetyltransferase binding
GO:0035108 IMP limb morphogenesis
GO:0035295 IGI tube development
GO:0042060 IEA wound healing
GO:0042127 IGI regulation of cell proliferation
GO:0042307 IGI positive regulation of protein import into nucleus
GO:0042475 IGI odontogenesis of dentin-containing tooth
GO:0042733 IMP embryonic digit morphogenesis
GO:0042826 IEA histone deacetylase binding
GO:0042981 IMP regulation of apoptotic process
GO:0043010 IGI camera-type eye development
GO:0043066 IMP negative regulation of apoptotic process
GO:0043565 IDA sequence-specific DNA binding
GO:0043586 IMP tongue development
GO:0043627 IEA response to estrogen
GO:0045060 IMP negative thymic T cell selection
GO:0045595 IGI regulation of cell differentiation
GO:0045596 IGI negative regulation of cell differentiation
GO:0045665 IMP negative regulation of neuron differentiation
GO:0045669 IGI positive regulation of osteoblast differentiation
GO:0045879 IMP negative regulation of smoothened signaling pathway
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046638 IMP positive regulation of alpha-beta T cell differentiation
GO:0046639 IMP negative regulation of alpha-beta T cell differentiation
GO:0046872 IEA metal ion binding
GO:0048557 IMP embryonic digestive tract morphogenesis
GO:0048566 IMP embryonic digestive tract development
GO:0048589 IMP developmental growth
GO:0048593 IMP camera-type eye morphogenesis
GO:0048598 IMP embryonic morphogenesis
GO:0048646 IGI anatomical structure formation involved in morphogenesis
GO:0048663 IMP neuron fate commitment
GO:0048704 IGI embryonic skeletal system morphogenesis
GO:0048709 IGI oligodendrocyte differentiation
GO:0048754 IMP branching morphogenesis of an epithelial tube
GO:0048839 IGI inner ear development
GO:0048856 IGI anatomical structure development
GO:0060021 IMP palate development
GO:0060173 IMP limb development
GO:0060364 IMP frontal suture morphogenesis
GO:0060366 IMP lambdoid suture morphogenesis
GO:0060367 IMP sagittal suture morphogenesis
GO:0060594 IGI mammary gland specification
GO:0060831 IGI smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0060840 IGI artery development
GO:0060873 IMP anterior semicircular canal development
GO:0060875 IMP lateral semicircular canal development
GO:0061005 IGI cell differentiation involved in kidney development
GO:0070242 IMP thymocyte apoptotic process
GO:0072372 IDA primary cilium
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000123101 gli1-202 protein_coding Danio_rerio 0 399
ENSDART00000049151 gli1-201 protein_coding Danio_rerio 0 399
ENST00000395925 GLI3-001 protein_coding Homo_sapiens 0 5064
ENST00000448703 GLI3-005 protein_coding Homo_sapiens 0 689
ENST00000464291 GLI3-006 retained_intron Homo_sapiens 0 486
ENST00000479210 GLI3-002 processed_transcript Homo_sapiens 0 4826

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