C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: protein tyrosine phosphatase, receptor type, C
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000442510 PTPRC-001 ENSG00000081237 9606 + 1:198639040-198757283 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBreastColonHeartLiverLungOvaryENST00000442510
Transcript ID Adipose Adrenal Breast Colon Heart Liver Lung Ovary
ENST00000442510 0.510±0.00 6.692±0.00 3.932±0.00 3.208±0.00 0.232±0.00 0.880±0.59 7.992±3.92 0.213±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00093I CIL_00093I_0001 VISTA 1:198070272-198672477

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000187 IEA activation of MAPK activity
GO:0001915 ISS negative regulation of T cell mediated cytotoxicity
GO:0001916 IEA positive regulation of T cell mediated cytotoxicity
GO:0001960 ISS negative regulation of cytokine-mediated signaling pathway
GO:0002244 IMP hematopoietic progenitor cell differentiation
GO:0002378 IMP immunoglobulin biosynthetic process
GO:0002711 IEA positive regulation of T cell mediated immunity
GO:0002923 IEA regulation of humoral immune response mediated by circulating immunoglobulin
GO:0002925 IEA positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0004725 IDA:IEA protein tyrosine phosphatase activity
GO:0005001 TAS transmembrane receptor protein tyrosine phosphatase activity
GO:0005515 IPI:IEA protein binding
GO:0005886 TAS plasma membrane
GO:0005887 ISS integral component of plasma membrane
GO:0005925 ISS focal adhesion
GO:0006469 ISS negative regulation of protein kinase activity
GO:0006470 ISS:IEA protein dephosphorylation
GO:0006933 IMP negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007159 IEA leukocyte cell-cell adhesion
GO:0007166 TAS cell surface receptor signaling pathway
GO:0007411 TAS axon guidance
GO:0008201 IEA heparin binding
GO:0009897 IDA external side of plasma membrane
GO:0009986 IEA cell surface
GO:0010332 IEA response to gamma radiation
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0016311 ISS:IEA dephosphorylation
GO:0016791 IEA phosphatase activity
GO:0019901 IPI protein kinase binding
GO:0030183 IEA B cell differentiation
GO:0030217 ISS T cell differentiation
GO:0030890 IMP positive regulation of B cell proliferation
GO:0031953 IEA negative regulation of protein autophosphorylation
GO:0034113 IEA heterotypic cell-cell adhesion
GO:0035335 IEA peptidyl-tyrosine dephosphorylation
GO:0042098 IEA T cell proliferation
GO:0042100 ISS B cell proliferation
GO:0042102 ISS positive regulation of T cell proliferation
GO:0043395 IEA heparan sulfate proteoglycan binding
GO:0043410 IEA positive regulation of MAPK cascade
GO:0044770 IMP cell cycle phase transition
GO:0045059 IEA positive thymic T cell selection
GO:0045060 IEA negative thymic T cell selection
GO:0045577 IEA regulation of B cell differentiation
GO:0045582 IEA positive regulation of T cell differentiation
GO:0045588 IEA positive regulation of gamma-delta T cell differentiation
GO:0045860 NAS positive regulation of protein kinase activity
GO:0046641 IEA positive regulation of alpha-beta T cell proliferation
GO:0048304 IEA positive regulation of isotype switching to IgG isotypes
GO:0048539 IMP bone marrow development
GO:0048864 IMP stem cell development
GO:0050732 IEA negative regulation of peptidyl-tyrosine phosphorylation
GO:0050852 IDA:IEA T cell receptor signaling pathway
GO:0050853 ISS B cell receptor signaling pathway
GO:0050855 IEA regulation of B cell receptor signaling pathway
GO:0050857 ISS positive regulation of antigen receptor-mediated signaling pathway
GO:0051209 ISS release of sequestered calcium ion into cytosol
GO:0051607 ISS defense response to virus
GO:0051726 ISS regulation of cell cycle
GO:0070062 IDA extracellular vesicular exosome
GO:0071944 IEA cell periphery
GO:2000473 IMP positive regulation of hematopoietic stem cell migration
GO:2000648 IMP positive regulation of stem cell proliferation
GO:2001236 IEA regulation of extrinsic apoptotic signaling pathway
GO:2001238 IEA positive regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000182755 Ptprc-003 protein_coding Mus_musculus 0 2143
ENSMUST00000183301 Ptprc-001 protein_coding Mus_musculus 0 2143
ENSMUST00000182283 Ptprc-002 protein_coding Mus_musculus 0 2143
ENSMUST00000112036 Ptprc-009 retained_intron Mus_musculus 0 2143
ENSMUST00000183262 Ptprc-004 retained_intron Mus_musculus 0 254
ENSMUST00000182138 Ptprc-007 retained_intron Mus_musculus 0 206

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