C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: early growth response 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000239938 EGR1-001 ENSG00000120738 9606 + 5:138465490-138469315 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000239938
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000239938 298.150±0.00 104.972±0.00 5.117±0.00 9.378±6.55 156.874±149.04 29.049±26.56 3.312±2.44 16.576±16.05 26.947±22.21 36.046±33.19 9.666±2.46 124.827±118.46 44.308±1.19 17.622±10.39

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005DD CIL_0005DD_0001 CGP 5:138439017-138469315
CIL_0005DC CIL_0005DC_0001 CGP 5:138465490-138543300

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000976 IDA transcription regulatory region sequence-specific DNA binding
GO:0000977 IEA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000979 IEA RNA polymerase II core promoter sequence-specific DNA binding
GO:0000982 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001975 IEA response to amphetamine
GO:0003677 IDA DNA binding
GO:0003690 IEA double-stranded DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 ISS cytoplasm
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0007611 IEA learning or memory
GO:0007623 IEA circadian rhythm
GO:0008134 IEA transcription factor binding
GO:0009749 IEA response to glucose
GO:0010628 IEA positive regulation of gene expression
GO:0010942 IEA positive regulation of cell death
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0030217 IEA T cell differentiation
GO:0030509 IEA BMP signaling pathway
GO:0031667 IEA response to nutrient levels
GO:0032354 IEA response to follicle-stimulating hormone
GO:0032868 IEA response to insulin
GO:0032869 IEA cellular response to insulin stimulus
GO:0033233 IDA regulation of protein sumoylation
GO:0034465 IEA response to carbon monoxide
GO:0034698 IEA response to gonadotropin
GO:0035035 IPI histone acetyltransferase binding
GO:0035690 IEA cellular response to drug
GO:0035914 IBA skeletal muscle cell differentiation
GO:0042220 IEA response to cocaine
GO:0042493 IEA response to drug
GO:0043066 IBA negative regulation of apoptotic process
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045471 IEA response to ethanol
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0048169 IBA regulation of long-term neuronal synaptic plasticity
GO:0048709 IEA oligodendrocyte differentiation
GO:0051602 IEA response to electrical stimulus
GO:0060291 IEA long-term synaptic potentiation
GO:0060337 TAS type I interferon signaling pathway
GO:0070498 IMP interleukin-1-mediated signaling pathway
GO:0071236 IEA cellular response to antibiotic
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071310 IEA cellular response to organic substance
GO:0071317 IEA cellular response to isoquinoline alkaloid
GO:0071320 IBA cellular response to cAMP
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071371 IBA cellular response to gonadotropin stimulus
GO:0071372 IEA cellular response to follicle-stimulating hormone stimulus
GO:0071383 IEA cellular response to steroid hormone stimulus
GO:0071455 IEA cellular response to hyperoxia
GO:0071456 IEA cellular response to hypoxia
GO:0071480 IEA cellular response to gamma radiation
GO:0071504 ISS cellular response to heparin
GO:0071506 ISS cellular response to mycophenolic acid
GO:0071873 IEA response to norepinephrine
GO:0072110 ISS glomerular mesangial cell proliferation
GO:0072303 ISS positive regulation of glomerular metanephric mesangial cell proliferation
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000064795 Egr1-001 protein_coding Mus_musculus 0 3142
ENSMUST00000165033 Egr1-201 protein_coding Mus_musculus 0 2998
ENSMUST00000095759 Egr4-201 protein_coding Mus_musculus 0 224

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