C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: interferon regulatory factor 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000245414 IRF1-001 ENSG00000125347 9606 - 5:132481609-132490798 protein_coding

Homo sapiens EnsemblGRCh38

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Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000245414
Transcript ID Adipose Adrenal Brain Breast Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000245414 0.871±0.00 3.517±0.00 1.061±0.00 1.690±0.00 0.722±0.00 2.758±0.00 0.896±0.24 29.224±0.00 1.107±0.00 1.746±0.74 2.390±0.95 1.325±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00093D CIL_00093D_0001 VISTA 5:131965137-132566411
CIL_0007RF CIL_0007RF_0001 VISTA 5:131967147-132570227

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000790 IDA nuclear chromatin
GO:0000975 IEA regulatory region DNA binding
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0002819 TAS regulation of adaptive immune response
GO:0003677 TAS DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 TAS nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 ISS cytoplasm
GO:0005829 TAS cytosol
GO:0006366 TAS transcription from RNA polymerase II promoter
GO:0006915 IDA apoptotic process
GO:0007050 IDA cell cycle arrest
GO:0007596 TAS blood coagulation
GO:0008285 TAS negative regulation of cell proliferation
GO:0010468 IEA regulation of gene expression
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0032481 ISS positive regulation of type I interferon production
GO:0032728 IMP positive regulation of interferon-beta production
GO:0034124 ISS regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0035458 IDA cellular response to interferon-beta
GO:0043374 IEA CD8-positive, alpha-beta T cell differentiation
GO:0043565 IEA sequence-specific DNA binding
GO:0045084 IEA positive regulation of interleukin-12 biosynthetic process
GO:0045088 TAS regulation of innate immune response
GO:0045590 ISS negative regulation of regulatory T cell differentiation
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0051607 IDA defense response to virus
GO:0051726 TAS regulation of cell cycle
GO:0060333 ISS interferon-gamma-mediated signaling pathway
GO:0060337 TAS type I interferon signaling pathway
GO:0071260 IEP cellular response to mechanical stimulus
GO:2000564 ISS regulation of CD8-positive, alpha-beta T cell proliferation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000108920 Irf1-001 protein_coding Mus_musculus 0 1306
ENSMUST00000019043 Irf1-002 protein_coding Mus_musculus 0 1277
ENSMUST00000108922 Irf1-008 protein_coding Mus_musculus 0 918
ENSMUST00000140866 Irf1-010 protein_coding Mus_musculus 0 680
ENSMUST00000123376 Irf1-005 protein_coding Mus_musculus 0 647
ENSMUST00000133291 Irf1-006 protein_coding Mus_musculus 0 564
ENSMUST00000138913 Irf1-007 protein_coding Mus_musculus 0 285
ENSMUST00000142221 Irf1-009 nonsense_mediated_decay Mus_musculus 8e-39 167
ENSMUST00000170390 Gm17334-201 protein_coding Mus_musculus 6e-35 154
ENSMUST00000173269 Neu1-002 retained_intron Mus_musculus 0.0002 53

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