C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: APH1B gamma secretase subunit
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000261879 APH1B-001 ENSG00000138613 9606 + 15:63277554-63309126 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000261879
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000261879 3.063±0.00 3.660±0.00 0.628±0.00 2.740±1.69 1.744±0.97 0.663±0.42 0.283±0.00 3.463±0.00 1.471±0.77 1.333±0.95 1.076±0.00 3.372±1.82 3.035±0.13 5.577±1.41

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00094O CIL_00094O_0001 VISTA 15:62748846-63351985
CIL_00098V CIL_00098V_0001 VISTA 15:62790346-63394142

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005886 TAS plasma membrane
GO:0007219 TAS Notch signaling pathway
GO:0007220 TAS Notch receptor processing
GO:0008233 IDA peptidase activity
GO:0016021 IEA:IDA integral component of membrane
GO:0016485 IEA:IDA protein processing
GO:0030133 IDA transport vesicle
GO:0031293 TAS membrane protein intracellular domain proteolysis
GO:0043065 TAS positive regulation of apoptotic process
GO:0043085 IEA positive regulation of catalytic activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000034934 Aph1b-001 protein_coding Mus_musculus 0 913
ENSMUST00000169282 Aph1c-001 protein_coding Mus_musculus 0 857
ENSMUST00000057261 Aph1c-002 protein_coding Mus_musculus 0 713
ENSMUST00000168309 Aph1b-002 nonsense_mediated_decay Mus_musculus 0 573
ENSMUST00000113730 Aph1b-003 protein_coding Mus_musculus 0 313

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