C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: E1A binding protein p300
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000263253 EP300-001 ENSG00000100393 9606 + 22:41091786-41180077 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000263253
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000263253 7.959±0.00 4.602±0.00 3.149±0.00 4.372±1.35 4.977±1.13 3.763±2.22 6.474±0.00 5.198±2.46 4.598±1.40 6.270±0.51 4.132±3.30 5.737±3.52 8.272±2.40 12.332±0.12

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006RK CIL_0006RK_0001 CGP 22:41091786-41231271

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000086 TAS G2/M transition of mitotic cell cycle
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000123 IEA histone acetyltransferase complex
GO:0000278 TAS mitotic cell cycle
GO:0000979 IEA RNA polymerase II core promoter sequence-specific DNA binding
GO:0001047 IDA core promoter binding
GO:0001085 IEA RNA polymerase II transcription factor binding
GO:0001102 IPI RNA polymerase II activating transcription factor binding
GO:0001666 IDA response to hypoxia
GO:0001756 IEA somitogenesis
GO:0002039 IEA p53 binding
GO:0003677 IDA DNA binding
GO:0003682 IMP chromatin binding
GO:0003712 IEA transcription cofactor activity
GO:0003713 IDA:IEA transcription coactivator activity
GO:0004402 IDA:IEA histone acetyltransferase activity
GO:0004468 IDA lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0006325 TAS chromatin organization
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA:IEA regulation of transcription, DNA-templated
GO:0006475 IDA internal protein amino acid acetylation
GO:0006915 IMP apoptotic process
GO:0007219 TAS Notch signaling pathway
GO:0007399 TAS nervous system development
GO:0007507 IEA heart development
GO:0007519 IEA skeletal muscle tissue development
GO:0007623 ISS circadian rhythm
GO:0008013 IPI beta-catenin binding
GO:0008134 IPI transcription factor binding
GO:0008270 IEA zinc ion binding
GO:0009887 IEA organ morphogenesis
GO:0016032 IEA viral process
GO:0016407 IMP acetyltransferase activity
GO:0016573 IEA histone acetylation
GO:0016746 IDA transferase activity, transferring acyl groups
GO:0018076 IDA N-terminal peptidyl-lysine acetylation
GO:0018393 IDA internal peptidyl-lysine acetylation
GO:0030324 IEA lung development
GO:0031490 IEA chromatin DNA binding
GO:0032092 IEA positive regulation of protein binding
GO:0032481 TAS positive regulation of type I interferon production
GO:0033613 IPI activating transcription factor binding
GO:0035257 IPI nuclear hormone receptor binding
GO:0042771 IDA intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043627 IDA response to estrogen
GO:0043923 IDA positive regulation by host of viral transcription
GO:0043967 IMP histone H4 acetylation
GO:0043969 IDA histone H2B acetylation
GO:0045087 TAS innate immune response
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0050681 IPI androgen receptor binding
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051726 TAS regulation of cell cycle
GO:0060765 IDA regulation of androgen receptor signaling pathway
GO:0061418 TAS regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456 TAS cellular response to hypoxia
GO:0090043 IDA regulation of tubulin deacetylation
GO:0097157 IEA pre-mRNA intronic binding

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000068387 Ep300-001 protein_coding Mus_musculus 0 10670
ENSMUST00000189338 Ep300-002 retained_intron Mus_musculus 0 3203
ENSMUST00000023165 Crebbp-001 protein_coding Mus_musculus 0 1513
ENSDART00000114629 ep300a-202 protein_coding Danio_rerio 0 1495
ENSDART00000087250 crebbpa-201 protein_coding Danio_rerio 0 1334
ENSDART00000148002 crebbpa-001 protein_coding Danio_rerio 0 1334
ENSDART00000091873 crebbpb-201 protein_coding Danio_rerio 0 1249
ENSDART00000149691 ep300a-001 protein_coding Danio_rerio 0 1090
ENSMUST00000185375 Ep300-004 retained_intron Mus_musculus 0 939
ENSMUST00000187776 Ep300-003 retained_intron Mus_musculus 0 808
ENSDART00000115164 CREBBP (1 of 3)-201 protein_coding Danio_rerio 0 566
ENSMUST00000185967 Ep300-006 protein_coding Mus_musculus 0 435

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