C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000269571 ERBB2-008 ENSG00000141736 9606 + 17:39700080-39728662 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; HeartLungOvaryENST00000269571
Transcript ID Heart Lung Ovary
ENST00000269571 3.548±2.54 1.967±0.00 24.719±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008SN CIL_0008SN_0001 VISTA 17:39110111-39710718
CIL_00080Z CIL_00080Z_0001 VISTA 17:39318232-39918735
CIL_00098W CIL_00098W_0001 VISTA 17:39359510-39962707
CIL_0007WH CIL_0007WH_0001 VISTA 17:39374871-39978277
CIL_0002PP CIL_0002PP_0001 CGP 17:39667981-39696797
CIL_0002PO CIL_0002PO_0001 CGP 17:39671122-39730426
CIL_0002PN CIL_0002PN_0001 CGP 17:39687914-39730787

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001042 IDA RNA polymerase I core binding
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0004672 IEA protein kinase activity
GO:0004713 IDA:IEA protein tyrosine kinase activity
GO:0004714 IEA:IDA transmembrane receptor protein tyrosine kinase activity
GO:0004716 IEA receptor signaling protein tyrosine kinase activity
GO:0004888 IDA transmembrane signaling receptor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006468 TAS:IEA protein phosphorylation
GO:0007165 IDA signal transduction
GO:0007166 IDA cell surface receptor signaling pathway
GO:0007167 TAS enzyme linked receptor protein signaling pathway
GO:0007169 IEA:IDA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007399 IEA nervous system development
GO:0007411 TAS axon guidance
GO:0007422 IEA peripheral nervous system development
GO:0007507 IEA heart development
GO:0007528 IEA neuromuscular junction development
GO:0008022 IPI protein C-terminus binding
GO:0008045 IEA motor neuron axon guidance
GO:0008283 TAS cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0010008 IDA endosome membrane
GO:0014065 IDA phosphatidylinositol 3-kinase signaling
GO:0016020 IEA membrane
GO:0016021 NAS:IEA integral component of membrane
GO:0016323 IDA basolateral plasma membrane
GO:0016324 IEA apical plasma membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019838 IDA growth factor binding
GO:0019903 IPI protein phosphatase binding
GO:0023014 IEA signal transduction by phosphorylation
GO:0030307 IMP positive regulation of cell growth
GO:0031410 IEA cytoplasmic vesicle
GO:0032321 ISS positive regulation of Rho GTPase activity
GO:0032886 IDA regulation of microtubule-based process
GO:0033088 IEA negative regulation of immature T cell proliferation in thymus
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042060 IDA wound healing
GO:0042552 IEA myelination
GO:0042802 IPI identical protein binding
GO:0043125 TAS ErbB-3 class receptor binding
GO:0043235 IDA receptor complex
GO:0043406 IDA positive regulation of MAP kinase activity
GO:0045087 TAS innate immune response
GO:0045727 IMP positive regulation of translation
GO:0045765 NAS regulation of angiogenesis
GO:0045785 IDA positive regulation of cell adhesion
GO:0045943 IMP positive regulation of transcription from RNA polymerase I promoter
GO:0045945 IDA positive regulation of transcription from RNA polymerase III promoter
GO:0046777 IDA protein autophosphorylation
GO:0046982 IDA protein heterodimerization activity
GO:0046983 NAS protein dimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048709 IEA oligodendrocyte differentiation
GO:0050679 IDA positive regulation of epithelial cell proliferation
GO:0070372 IMP regulation of ERK1 and ERK2 cascade

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000058295 Erbb2-001 protein_coding Mus_musculus 0 4076
ENSMUST00000136032 Erbb2-002 processed_transcript Mus_musculus 0 2093

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