C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000288368 PREX2-001 ENSG00000046889 9606 + 8:67952118-68237030 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000288368
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000288368 3.133±0.00 0.773±0.00 0.183±0.00 2.676±0.15 3.204±0.00 1.373±0.58 1.419±0.55 0.585±0.48 1.472±1.13 1.368±0.22 0.292±0.19 0.427±0.16 1.210±0.24 1.275±0.83

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005BU CIL_0005BU_0002 CGP 8:67422125-68237030
CIL_00087Z CIL_00087Z_0001 VISTA 8:67680490-68283275
CIL_0001SD CIL_0001SD_0002 CGP 8:67952118-68819022

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IEA protein binding
GO:0005886 IEA plasma membrane
GO:0007186 IDA G-protein coupled receptor signaling pathway
GO:0008344 IEA adult locomotory behavior
GO:0014065 IEA phosphatidylinositol 3-kinase signaling
GO:0030675 IDA Rac GTPase activator activity
GO:0030676 IDA Rac guanyl-nucleotide exchange factor activity
GO:0032855 IDA positive regulation of Rac GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0048813 IEA dendrite morphogenesis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000027056 Prex2-001 protein_coding Mus_musculus 0 5384
ENSMUST00000189822 Prex2-003 retained_intron Mus_musculus 0 1565
ENSMUST00000187694 Prex2-004 retained_intron Mus_musculus 0 747
ENSMUST00000190935 Prex2-002 retained_intron Mus_musculus 5e-35 156

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