C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: tuberous sclerosis 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000298552 TSC1-001 ENSG00000165699 9606 - 9:132891348-132944621 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartLiverLungMuscleOvaryPlacentaTestisENST00000298552
Transcript ID Adipose Bladder Brain Breast Colon Heart Liver Lung Muscle Ovary Placenta Testis
ENST00000298552 2.435±0.00 1.852±0.00 2.482±0.26 1.948±0.75 1.134±0.05 2.575±0.00 0.890±0.00 2.285±0.00 1.467±1.00 1.563±1.54 3.046±0.00 4.298±0.31

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001822 IEA kidney development
GO:0001843 IEA neural tube closure
GO:0001952 IMP regulation of cell-matrix adhesion
GO:0005488 IEA binding
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0005856 IEA cytoskeleton
GO:0005884 IDA actin filament
GO:0005938 IDA cell cortex
GO:0006407 IMP rRNA export from nucleus
GO:0006417 IDA regulation of translation
GO:0006813 IEA potassium ion transport
GO:0007050 TAS cell cycle arrest
GO:0007160 IMP cell-matrix adhesion
GO:0007399 IEA nervous system development
GO:0008285 IMP negative regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0016020 IDA membrane
GO:0017148 IMP negative regulation of translation
GO:0021766 IEA hippocampus development
GO:0021987 IEA cerebral cortex development
GO:0030027 IDA lamellipodium
GO:0030030 IEA cell projection organization
GO:0030426 IEA growth cone
GO:0030695 IBA GTPase regulator activity
GO:0032007 IMP negative regulation of TOR signaling
GO:0032794 IEA GTPase activating protein binding
GO:0032862 IDA activation of Rho GTPase activity
GO:0032868 IDA response to insulin
GO:0032956 IEA regulation of actin cytoskeleton organization
GO:0033596 IDA TSC1-TSC2 complex
GO:0042552 IEA myelination
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043234 IDA protein complex
GO:0043666 IMP regulation of phosphoprotein phosphatase activity
GO:0045792 IEA negative regulation of cell size
GO:0045859 IEA regulation of protein kinase activity
GO:0046323 IEA glucose import
GO:0046627 IBA negative regulation of insulin receptor signaling pathway
GO:0047485 IPI protein N-terminus binding
GO:0050808 IEA synapse organization
GO:0050821 IDA protein stabilization
GO:0051087 IPI chaperone binding
GO:0051291 IEA protein heterooligomerization
GO:0051492 IDA regulation of stress fiber assembly
GO:0051726 IBA regulation of cell cycle
GO:0051893 IEA regulation of focal adhesion assembly
GO:0051894 IDA positive regulation of focal adhesion assembly
GO:0055007 IEA cardiac muscle cell differentiation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000113869 Tsc1-001 protein_coding Mus_musculus 0 4100
ENSMUST00000133565 Tsc1-004 nonsense_mediated_decay Mus_musculus 0 4063
ENSMUST00000113867 Tsc1-007 protein_coding Mus_musculus 0 3986
ENSMUST00000028155 Tsc1-002 protein_coding Mus_musculus 0 3954
ENSMUST00000113870 Tsc1-201 protein_coding Mus_musculus 0 3879
ENSMUST00000156857 Tsc1-003 nonsense_mediated_decay Mus_musculus 0 1478
ENSMUST00000153625 Tsc1-006 retained_intron Mus_musculus 0 1352
ENSMUST00000124507 Tsc1-008 retained_intron Mus_musculus 0 894
ENSMUST00000150274 Tsc1-009 retained_intron Mus_musculus 0 483

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