C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: leucine-rich repeat kinase 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000298910 LRRK2-004 ENSG00000188906 9606 + 12:40225074-40369281 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000298910
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000298910 0.658±0.00 0.486±0.00 4.126±0.00 1.037±0.04 0.943±0.45 1.249±0.00 0.525±0.04 2.255±0.00 0.910±0.00 8.679±4.88 0.717±0.00 0.487±0.07 0.184±0.00 0.603±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006R2 CIL_0006R2_0001 CGP 12:39755021-40369285

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000149 IPI SNARE binding
GO:0000165 IDA MAPK cascade
GO:0000186 IDA activation of MAPKK activity
GO:0000187 IDA activation of MAPK activity
GO:0001933 ISS negative regulation of protein phosphorylation
GO:0001934 IMP positive regulation of protein phosphorylation
GO:0001948 IPI glycoprotein binding
GO:0003779 IPI actin binding
GO:0003924 IDA GTPase activity
GO:0004672 IDA:IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004708 IDA MAP kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005096 IDA GTPase activator activity
GO:0005488 IEA binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005525 IDA:IEA GTP binding
GO:0005615 IDA extracellular space
GO:0005622 IEA intracellular
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005741 ISS mitochondrial outer membrane
GO:0005743 ISS mitochondrial inner membrane
GO:0005759 ISS mitochondrial matrix
GO:0005764 ISS lysosome
GO:0005768 ISS endosome
GO:0005783 ISS endoplasmic reticulum
GO:0005794 ISS Golgi apparatus
GO:0005802 IEA trans-Golgi network
GO:0005829 IDA cytosol
GO:0005886 IEA plasma membrane
GO:0006184 IDA GTP catabolic process
GO:0006468 IMP:IEA protein phosphorylation
GO:0006897 IGI endocytosis
GO:0006914 IEA autophagy
GO:0006979 IMP response to oxidative stress
GO:0007264 IEA small GTPase mediated signal transduction
GO:0007528 IMP neuromuscular junction development
GO:0008021 IEA synaptic vesicle
GO:0008340 IMP determination of adult lifespan
GO:0010508 ISS positive regulation of autophagy
GO:0010738 ISS regulation of protein kinase A signaling
GO:0010955 IDA negative regulation of protein processing
GO:0014041 IMP regulation of neuron maturation
GO:0015031 IEA protein transport
GO:0015631 IDA tubulin binding
GO:0016020 IEA membrane
GO:0016234 IMP inclusion body
GO:0016301 IDA kinase activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017048 IPI Rho GTPase binding
GO:0017075 IPI syntaxin-1 binding
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0021772 IMP olfactory bulb development
GO:0022028 IMP tangential migration from the subventricular zone to the olfactory bulb
GO:0030276 IPI clathrin binding
GO:0030424 ISS axon
GO:0030425 ISS dendrite
GO:0031398 IDA positive regulation of protein ubiquitination
GO:0031410 ISS cytoplasmic vesicle
GO:0031966 IDA mitochondrial membrane
GO:0032091 IMP negative regulation of protein binding
GO:0032092 IDA positive regulation of protein binding
GO:0032436 ISS positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032473 IDA cytoplasmic side of mitochondrial outer membrane
GO:0032839 IDA dendrite cytoplasm
GO:0034211 IMP GTP-dependent protein kinase activity
GO:0034260 IDA negative regulation of GTPase activity
GO:0034599 IMP cellular response to oxidative stress
GO:0034613 ISS cellular protein localization
GO:0035556 ISS intracellular signal transduction
GO:0035564 ISS regulation of kidney size
GO:0035640 IMP exploration behavior
GO:0035641 IEA locomotory exploration behavior
GO:0036479 IDA peroxidase inhibitor activity
GO:0040012 IMP regulation of locomotion
GO:0042391 IMP regulation of membrane potential
GO:0042802 IPI identical protein binding
GO:0042803 IPI protein homodimerization activity
GO:0043005 IDA neuron projection
GO:0043025 IDA neuronal cell body
GO:0043068 IDA positive regulation of programmed cell death
GO:0043195 TAS terminal bouton
GO:0043204 ISS perikaryon
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043406 IC positive regulation of MAP kinase activity
GO:0043547 IEA positive regulation of GTPase activity
GO:0044325 IPI ion channel binding
GO:0045121 IEA membrane raft
GO:0045202 IEA synapse
GO:0046777 IDA protein autophosphorylation
GO:0048312 IMP intracellular distribution of mitochondria
GO:0048812 IMP neuron projection morphogenesis
GO:0051018 IPI protein kinase A binding
GO:0051900 IMP regulation of mitochondrial depolarization
GO:0051966 ISS regulation of synaptic transmission, glutamatergic
GO:0060079 ISS regulation of excitatory postsynaptic membrane potential
GO:0060159 ISS regulation of dopamine receptor signaling pathway
GO:0060161 IMP positive regulation of dopamine receptor signaling pathway
GO:0061001 ISS regulation of dendritic spine morphogenesis
GO:0070062 IDA extracellular vesicular exosome
GO:0070585 TAS protein localization to mitochondrion
GO:0070997 IMP neuron death
GO:0071287 IMP cellular response to manganese ion
GO:0071407 IEA cellular response to organic cyclic compound
GO:0072593 IMP reactive oxygen species metabolic process
GO:0090140 TAS regulation of mitochondrial fission
GO:1901214 IMP regulation of neuron death
GO:1902499 IDA positive regulation of protein autoubiquitination
GO:1902692 IMP regulation of neuroblast proliferation
GO:1902803 ISS regulation of synaptic vesicle transport
GO:1902823 TAS negative regulation of late endosome to lysosome transport
GO:1903125 IDA negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
GO:1903206 IMP negative regulation of hydrogen peroxide-induced cell death
GO:1903215 IDA negative regulation of protein targeting to mitochondrion
GO:1903217 IC negative regulation of protein processing involved in protein targeting to mitochondrion
GO:1903351 IMP cellular response to dopamine
GO:2000172 IMP regulation of branching morphogenesis of a nerve
GO:2000300 IMP regulation of synaptic vesicle exocytosis
GO:2000469 IDA negative regulation of peroxidase activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000060642 Lrrk2-001 protein_coding Mus_musculus 0 6988
ENSMUST00000140734 Lrrk2-002 processed_transcript Mus_musculus 0 2948
ENSMUST00000133743 Lrrk2-003 processed_transcript Mus_musculus 0 1596
ENSMUST00000137657 Lrrk2-004 retained_intron Mus_musculus 0 523
ENSMUST00000156900 Lrrk2-005 processed_transcript Mus_musculus 0 520
ENSMUST00000172797 Lrrk2-006 retained_intron Mus_musculus 0 213

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