C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: polo-like kinase 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000300093 PLK1-001 ENSG00000166851 9606 + 16:23678822-23690367 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBreastHeartLiverLungOvaryPlacentaTestisENST00000300093
Transcript ID Adipose Breast Heart Liver Lung Ovary Placenta Testis
ENST00000300093 0.259±0.00 0.266±0.00 0.210±0.00 0.101±0.00 0.360±0.00 5.157±5.85 7.005±2.37 24.730±3.24

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006D0 CIL_0006D0_0001 CGP 16:23641392-23690367
CIL_0003VD CIL_0003VD_0002 CGP 16:23677656-23713500

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000070 IMP mitotic sister chromatid segregation
GO:0000086 IDA G2/M transition of mitotic cell cycle
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000278 TAS mitotic cell cycle
GO:0000281 IDA mitotic cytokinesis
GO:0000776 IDA kinetochore
GO:0000910 IMP cytokinesis
GO:0000922 IDA spindle pole
GO:0000942 IDA condensed nuclear chromosome outer kinetochore
GO:0001578 IDA microtubule bundle formation
GO:0004672 IEA:IDA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0005813 IDA centrosome
GO:0005819 IDA spindle
GO:0005829 TAS cytosol
GO:0005876 IDA spindle microtubule
GO:0006468 IEA:IDA protein phosphorylation
GO:0007067 IMP mitotic nuclear division
GO:0007077 TAS mitotic nuclear envelope disassembly
GO:0007091 TAS metaphase/anaphase transition of mitotic cell cycle
GO:0007092 IDA activation of mitotic anaphase-promoting complex activity
GO:0007094 IMP mitotic spindle assembly checkpoint
GO:0007346 IMP regulation of mitotic cell cycle
GO:0008017 IDA microtubule binding
GO:0008283 TAS cell proliferation
GO:0010800 IMP positive regulation of peptidyl-threonine phosphorylation
GO:0010997 IPI anaphase-promoting complex binding
GO:0015630 IDA microtubule cytoskeleton
GO:0016301 TAS kinase activity
GO:0016567 IDA protein ubiquitination
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0019901 IPI protein kinase binding
GO:0030071 IMP regulation of mitotic metaphase/anaphase transition
GO:0030496 IDA midbody
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031572 IDA G2 DNA damage checkpoint
GO:0031648 IDA protein destabilization
GO:0032436 IMP positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0040038 IEA polar body extrusion after meiotic divisions
GO:0043066 IMP negative regulation of apoptotic process
GO:0043393 IMP regulation of protein binding
GO:0045184 IMP establishment of protein localization
GO:0045736 IMP negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045862 IDA positive regulation of proteolysis
GO:0046677 IEA response to antibiotic
GO:0051233 IDA spindle midzone
GO:0051297 IMP centrosome organization
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051443 IMP positive regulation of ubiquitin-protein transferase activity
GO:0051726 TAS regulation of cell cycle
GO:0071168 IDA protein localization to chromatin

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000033154 Plk1-201 protein_coding Mus_musculus 0 2331
ENSMUST00000119494 Plk-ps1-001 processed_pseudogene Mus_musculus 0 1788

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