C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: twinfilin actin-binding protein 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000305533 TWF2-001 ENSG00000247596 9606 - 3:52228610-52239260 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000305533
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000305533 23.385±0.00 14.824±0.00 7.547±5.04 11.260±9.95 21.516±0.00 17.066±13.98 7.479±4.34 3.760±0.06 14.547±0.00 30.595±23.72 26.535±16.12 31.156±7.63 9.779±1.03

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00087C CIL_00087C_0001 VISTA 3:51705330-52307529
CIL_0008NT CIL_0008NT_0001 VISTA 3:51738719-52342071
CIL_0007WP CIL_0007WP_0001 VISTA 3:52127966-52731115

Gene Ontology

GO IDEvidence TypeGO Description
GO:0003779 IEA actin binding
GO:0003785 ISS actin monomer binding
GO:0005080 IPI protein kinase C binding
GO:0005524 IDA ATP binding
GO:0005546 ISS phosphatidylinositol-4,5-bisphosphate binding
GO:0005622 IEA intracellular
GO:0005737 NAS cytoplasm
GO:0005856 IEA cytoskeleton
GO:0010592 IMP positive regulation of lamellipodium assembly
GO:0010976 IMP positive regulation of neuron projection development
GO:0030016 ISS myofibril
GO:0030027 ISS lamellipodium
GO:0030030 IEA cell projection organization
GO:0030175 ISS filopodium
GO:0030426 IDA growth cone
GO:0030837 ISS negative regulation of actin filament polymerization
GO:0032420 ISS stereocilium
GO:0032532 IC regulation of microvillus length
GO:0032956 IMP regulation of actin cytoskeleton organization
GO:0042989 ISS sequestering of actin monomers
GO:0044822 IDA poly(A) RNA binding
GO:0045773 IMP positive regulation of axon extension
GO:0048471 ISS perinuclear region of cytoplasm
GO:0051016 ISS barbed-end actin filament capping
GO:0070062 IDA extracellular vesicular exosome
GO:0071300 IMP cellular response to retinoic acid
GO:0071363 IMP cellular response to growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000024047 Twf2-001 protein_coding Mus_musculus 0 1367
ENSMUST00000188650 Twf2-003 protein_coding Mus_musculus 0 1223
ENSMUST00000187647 Twf2-004 nonsense_mediated_decay Mus_musculus 0 544
ENSMUST00000189708 Twf2-005 retained_intron Mus_musculus 0 396

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