C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: cytochrome P450, family 3, subfamily A, polypeptide 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000336411 CYP3A4-001 ENSG00000160868 9606 - 7:99757676-99784265 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBreastColonKidneyLiverLungMusclePlacentaTestisENST00000336411
Transcript ID Adipose Bladder Breast Colon Kidney Liver Lung Muscle Placenta Testis
ENST00000336411 0.019±0.00 1.141±0.00 0.467±0.29 0.039±0.03 271.075±270.95 34.857±34.75 0.104±0.00 0.261±0.24 0.042±0.00 0.183±0.10

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005LC CIL_0005LC_0006 CGP 7:99684679-99784265
CIL_0008QI CIL_0008QI_0001 VISTA 7:99696610-100298804
CIL_0005LC CIL_0005LC_0005 CGP 7:99756960-99866102

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004497 ISS monooxygenase activity
GO:0005496 IDA steroid binding
GO:0005506 IDA:IEA iron ion binding
GO:0005737 IDA cytoplasm
GO:0005789 TAS endoplasmic reticulum membrane
GO:0006629 TAS lipid metabolic process
GO:0006706 IMP steroid catabolic process
GO:0006805 TAS xenobiotic metabolic process
GO:0008202 IMP steroid metabolic process
GO:0008209 TAS androgen metabolic process
GO:0008395 IMP steroid hydroxylase activity
GO:0009822 IDA alkaloid catabolic process
GO:0016021 IEA integral component of membrane
GO:0016098 IDA monoterpenoid metabolic process
GO:0016491 IDA oxidoreductase activity
GO:0016705 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0017144 IDA drug metabolic process
GO:0019825 TAS oxygen binding
GO:0019899 IPI enzyme binding
GO:0020037 IEA heme binding
GO:0030343 IDA vitamin D3 25-hydroxylase activity
GO:0033780 IEA taurochenodeoxycholate 6alpha-hydroxylase activity
GO:0034875 IDA caffeine oxidase activity
GO:0036378 IDA calcitriol biosynthetic process from calciol
GO:0042359 IC vitamin D metabolic process
GO:0042737 IDA drug catabolic process
GO:0042738 IDA exogenous drug catabolic process
GO:0043231 TAS intracellular membrane-bounded organelle
GO:0044281 TAS small molecule metabolic process
GO:0046483 IDA heterocycle metabolic process
GO:0047638 IEA albendazole monooxygenase activity
GO:0050591 IEA quinine 3-monooxygenase activity
GO:0050649 IMP testosterone 6-beta-hydroxylase activity
GO:0055114 IDA:IEA oxidation-reduction process
GO:0070576 IDA vitamin D 24-hydroxylase activity
GO:0070989 IDA oxidative demethylation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000031741 Cyp3a13-001 protein_coding Mus_musculus 0 1277
ENSMUST00000031633 Cyp3a16-001 protein_coding Mus_musculus 0 1005
ENSMUST00000067479 Cyp3a44-001 protein_coding Mus_musculus 0 935
ENSMUST00000068317 Cyp3a25-001 protein_coding Mus_musculus 0 917
ENSMUST00000035571 Cyp3a59-201 protein_coding Mus_musculus 0 911
ENSMUST00000079268 Cyp3a57-001 protein_coding Mus_musculus 0 867
ENSMUST00000145062 Cyp3a25-002 nonsense_mediated_decay Mus_musculus 0 592
ENSMUST00000174696 Cyp3a57-002 nonsense_mediated_decay Mus_musculus 0 525
ENSMUST00000153808 Cyp3a25-004 processed_transcript Mus_musculus 0 237

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