C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000337138 HIF1A-001 ENSG00000100644 9606 + 14:61695540-61748258 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000337138
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000337138 33.339±0.00 27.744±0.00 6.354±0.00 8.792±3.29 6.660±3.20 10.827±4.24 6.016±3.87 23.055±21.33 5.496±0.59 21.974±11.55 3.945±0.00 16.699±8.66 9.622±2.21 18.311±6.93

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000S0 CIL_0000S0_0001 CGP 14:61695513-61796428

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000989 IDA transcription factor binding transcription factor activity
GO:0001666 IDA response to hypoxia
GO:0001837 ISS epithelial to mesenchymal transition
GO:0001938 IC positive regulation of endothelial cell proliferation
GO:0002248 ISS connective tissue replacement involved in inflammatory response wound healing
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0004871 IEA signal transducer activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IPI transcription factor complex
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0006355 IDA:IEA regulation of transcription, DNA-templated
GO:0007165 IEA:IMP signal transduction
GO:0007219 TAS Notch signaling pathway
GO:0008134 IPI transcription factor binding
GO:0010468 IDA regulation of gene expression
GO:0010573 IDA vascular endothelial growth factor production
GO:0010575 IMP positive regulation vascular endothelial growth factor production
GO:0010634 ISS positive regulation of epithelial cell migration
GO:0010870 IMP positive regulation of receptor biosynthetic process
GO:0019896 IMP axon transport of mitochondrion
GO:0019899 IPI enzyme binding
GO:0019901 IPI protein kinase binding
GO:0030949 IC positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032364 IDA oxygen homeostasis
GO:0032722 TAS positive regulation of chemokine production
GO:0032909 IMP regulation of transforming growth factor beta2 production
GO:0032963 ISS collagen metabolic process
GO:0035035 IPI histone acetyltransferase binding
GO:0035257 IPI nuclear hormone receptor binding
GO:0042789 IC mRNA transcription from RNA polymerase II promoter
GO:0043565 IDA sequence-specific DNA binding
GO:0043619 IDA regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045648 IC positive regulation of erythrocyte differentiation
GO:0045766 IC positive regulation of angiogenesis
GO:0045821 IC positive regulation of glycolytic process
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046886 IDA positive regulation of hormone biosynthetic process
GO:0046982 IPI protein heterodimerization activity
GO:0046983 IEA protein dimerization activity
GO:0051000 TAS positive regulation of nitric-oxide synthase activity
GO:0051541 ISS elastin metabolic process
GO:0051879 IDA Hsp90 protein binding
GO:0061418 TAS regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061419 IMP positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070101 IC positive regulation of chemokine-mediated signaling pathway
GO:0071347 IEP cellular response to interleukin-1
GO:0071456 IDA cellular response to hypoxia
GO:1903377 IDA negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000110461 Hif1a-003 protein_coding Mus_musculus 0 3024
ENSMUST00000021530 Hif1a-001 protein_coding Mus_musculus 0 2113
ENSMUST00000110464 Hif1a-002 protein_coding Mus_musculus 0 1129
ENSMUST00000157041 Hif1a-005 processed_transcript Mus_musculus 0 466
ENSMUST00000149740 Hif1a-004 retained_intron Mus_musculus 0 340

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