C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000348035 RAC1-001 ENSG00000136238 9606 + 7:6374523-6403977 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000348035
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000348035 94.757±0.00 95.205±0.00 5.957±0.00 72.922±62.64 25.331±17.24 50.029±39.07 26.436±25.54 38.460±33.87 19.889±14.03 56.692±49.06 48.410±45.26 79.439±42.98 144.885±16.25 56.458±15.40

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001934 IMP positive regulation of protein phosphorylation
GO:0003924 TAS GTPase activity
GO:0005515 IPI protein binding
GO:0005525 IDA:IEA GTP binding
GO:0005622 IEA intracellular
GO:0005737 IDA cytoplasm
GO:0005802 IDA trans-Golgi network
GO:0005829 ISS cytosol
GO:0005884 IDA actin filament
GO:0005886 TAS plasma membrane
GO:0005925 IDA focal adhesion
GO:0006184 IEA GTP catabolic process
GO:0006928 TAS cellular component movement
GO:0006954 TAS inflammatory response
GO:0007155 TAS cell adhesion
GO:0007160 NAS cell-matrix adhesion
GO:0007165 IEA signal transduction
GO:0007264 IEA small GTPase mediated signal transduction
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0009611 TAS response to wounding
GO:0009653 TAS anatomical structure morphogenesis
GO:0010310 TAS regulation of hydrogen peroxide metabolic process
GO:0010592 IDA positive regulation of lamellipodium assembly
GO:0010811 IGI positive regulation of cell-substrate adhesion
GO:0015031 IEA protein transport
GO:0016020 ISS:IEA membrane
GO:0016032 TAS viral process
GO:0019899 IPI enzyme binding
GO:0030027 IDA lamellipodium
GO:0030032 IMP lamellipodium assembly
GO:0030036 IGI actin cytoskeleton organization
GO:0030041 TAS actin filament polymerization
GO:0030168 TAS platelet activation
GO:0030334 IMP regulation of cell migration
GO:0031295 TAS T cell costimulation
GO:0031529 IDA ruffle organization
GO:0031996 IPI thioesterase binding
GO:0032707 IDA negative regulation of interleukin-23 production
GO:0034446 IMP substrate adhesion-dependent cell spreading
GO:0035025 TAS positive regulation of Rho protein signal transduction
GO:0035556 TAS intracellular signal transduction
GO:0036464 IDA cytoplasmic ribonucleoprotein granule
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043065 TAS positive regulation of apoptotic process
GO:0045087 TAS innate immune response
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048261 TAS negative regulation of receptor-mediated endocytosis
GO:0048870 IDA cell motility
GO:0050690 TAS regulation of defense response to virus by virus
GO:0051022 ISS Rho GDP-dissociation inhibitor binding
GO:0051496 IDA positive regulation of stress fiber assembly
GO:0051668 IMP localization within membrane
GO:0051894 IDA positive regulation of focal adhesion assembly
GO:0060263 IDA regulation of respiratory burst
GO:0070062 IDA extracellular vesicular exosome
GO:0071526 ISS semaphorin-plexin signaling pathway
GO:0090023 IMP positive regulation of neutrophil chemotaxis
GO:0097190 TAS apoptotic signaling pathway
GO:1900026 IDA positive regulation of substrate adhesion-dependent cell spreading

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000080537 Rac1-001 protein_coding Mus_musculus 0 1057
ENSMUST00000100489 Rac1-002 protein_coding Mus_musculus 0 743
ENSMUST00000145709 Rac1-003 processed_transcript Mus_musculus 0 621
ENSMUST00000043214 Rac2-201 protein_coding Mus_musculus 0 392
ENSMUST00000131513 Rac1-004 processed_transcript Mus_musculus 0 254
ENSDART00000099388 rhoga-201 protein_coding Danio_rerio 9e-17 94
ENSDART00000152363 rhoga-001 protein_coding Danio_rerio 9e-17 94
ENSDART00000022562 rhogb-001 protein_coding Danio_rerio 0.0000000001 73
ENSMUST00000043382 4930544G11Rik-201 protein_coding Mus_musculus 0.00000002 66

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