C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: microphthalmia-associated transcription factor
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000352241 MITF-001 ENSG00000187098 9606 + 3:69739435-69968336 protein_coding

Homo sapiens EnsemblGRCh38

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Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000352241
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000352241 9.466±0.00 2.888±0.00 1.214±0.00 3.779±0.00 3.391±3.20 14.434±0.00 5.733±0.00 0.893±0.50 3.521±0.00 17.323±16.15 3.596±0.79 1.008±0.28 2.330±2.02

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001TC CIL_0001TC_0002 CGP 3:69169990-69968337

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 IEA RNA polymerase II core promoter sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001227 NAS RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003705 IEA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 NAS nucleus
GO:0006355 NAS:IEA regulation of transcription, DNA-templated
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006461 IDA protein complex assembly
GO:0010468 IEA regulation of gene expression
GO:0016055 IEA Wnt signaling pathway
GO:0030154 IEA cell differentiation
GO:0030316 IEA osteoclast differentiation
GO:0030318 NAS melanocyte differentiation
GO:0042127 IEA regulation of cell proliferation
GO:0043010 IEA camera-type eye development
GO:0043066 IEA negative regulation of apoptotic process
GO:0043234 IDA protein complex
GO:0043473 IEA pigmentation
GO:0044336 IEA canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0045165 IEA cell fate commitment
GO:0045670 IEA regulation of osteoclast differentiation
GO:0045893 NAS positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046849 IEA bone remodeling
GO:0046983 IEA protein dimerization activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000043637 Mitf-001 protein_coding Mus_musculus 0 2377
ENSMUST00000113339 Mitf-005 protein_coding Mus_musculus 0 2156
ENSMUST00000101123 Mitf-003 protein_coding Mus_musculus 0 2150
ENSMUST00000043628 Mitf-006 protein_coding Mus_musculus 0 1742
ENSMUST00000139462 Mitf-007 nonsense_mediated_decay Mus_musculus 0 1221
ENSMUST00000148233 Mitf-002 retained_intron Mus_musculus 0 628

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