C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Rho guanine nucleotide exchange factor (GEF) 12
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000356641 ARHGEF12-015 ENSG00000196914 9606 + 11:120336914-120487060 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; BreastColonMuscleOvaryTestisENST00000356641
Transcript ID Breast Colon Muscle Ovary Testis
ENST00000356641 6.880±0.00 8.531±0.00 1.891±0.00 2.738±0.00 2.201±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00021Z CIL_00021Z_0002 CGP 11:120325129-120489936

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001664 IDA G-protein coupled receptor binding
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005096 IEA GTPase activator activity
GO:0005515 IPI:IEA protein binding
GO:0005737 IEA:IDA cytoplasm
GO:0005829 TAS cytosol
GO:0007186 IDA G-protein coupled receptor signaling pathway
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007411 TAS axon guidance
GO:0016020 IEA membrane
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0038032 IEA termination of G-protein coupled receptor signaling pathway
GO:0043065 TAS positive regulation of apoptotic process
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0070062 IDA extracellular vesicular exosome
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000165665 Arhgef12-202 protein_coding Mus_musculus 0 5954
ENSMUST00000072767 Arhgef12-201 protein_coding Mus_musculus 0 5666

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