C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: cholinergic receptor, nicotinic, beta 2 (neuronal)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000368476 CHRNB2-001 ENSG00000160716 9606 + 1:154567781-154580026 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastColonHeartKidneyLungOvaryPlacentaTestisENST00000368476
Transcript ID Adrenal Brain Breast Colon Heart Kidney Lung Ovary Placenta Testis
ENST00000368476 0.105±0.00 5.159±2.15 0.149±0.00 0.101±0.02 0.023±0.01 0.083±0.00 0.110±0.08 0.117±0.06 0.008±0.00 0.720±0.28

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001508 IEA action potential
GO:0001661 IEA conditioned taste aversion
GO:0001666 IDA response to hypoxia
GO:0004889 TAS acetylcholine-activated cation-selective channel activity
GO:0005230 IEA extracellular ligand-gated ion channel activity
GO:0005515 IEA protein binding
GO:0005886 TAS plasma membrane
GO:0005892 IDA acetylcholine-gated channel complex
GO:0006810 IEA transport
GO:0006811 NAS:IEA ion transport
GO:0006816 ISS calcium ion transport
GO:0006939 ISS smooth muscle contraction
GO:0007165 IDA signal transduction
GO:0007268 TAS synaptic transmission
GO:0007271 ISS synaptic transmission, cholinergic
GO:0007601 ISS visual perception
GO:0007605 ISS sensory perception of sound
GO:0007612 IMP learning
GO:0007613 IMP memory
GO:0007626 ISS locomotory behavior
GO:0008144 IEA drug binding
GO:0008306 ISS associative learning
GO:0008542 IMP visual learning
GO:0009897 ISS external side of plasma membrane
GO:0014059 ISS regulation of dopamine secretion
GO:0015276 TAS ligand-gated ion channel activity
GO:0015464 IDA acetylcholine receptor activity
GO:0016020 IEA membrane
GO:0016021 NAS:IEA integral component of membrane
GO:0019233 ISS sensory perception of pain
GO:0021562 ISS vestibulocochlear nerve development
GO:0021631 ISS optic nerve morphogenesis
GO:0021771 ISS lateral geniculate nucleus development
GO:0021952 ISS central nervous system projection neuron axonogenesis
GO:0021955 IEA central nervous system neuron axonogenesis
GO:0030054 IEA cell junction
GO:0030890 ISS positive regulation of B cell proliferation
GO:0032225 ISS regulation of synaptic transmission, dopaminergic
GO:0032226 IEA positive regulation of synaptic transmission, dopaminergic
GO:0033603 ISS positive regulation of dopamine secretion
GO:0034220 TAS ion transmembrane transport
GO:0035094 IDA response to nicotine
GO:0035095 IMP behavioral response to nicotine
GO:0035176 ISS social behavior
GO:0042053 ISS regulation of dopamine metabolic process
GO:0042113 ISS B cell activation
GO:0042166 IMP acetylcholine binding
GO:0042220 ISS response to cocaine
GO:0042320 ISS regulation of circadian sleep/wake cycle, REM sleep
GO:0042391 IEA regulation of membrane potential
GO:0045188 IEA regulation of circadian sleep/wake cycle, non-REM sleep
GO:0045211 IEA postsynaptic membrane
GO:0045471 ISS response to ethanol
GO:0045759 ISS negative regulation of action potential
GO:0046982 IEA protein heterodimerization activity
GO:0048814 ISS regulation of dendrite morphogenesis
GO:0050877 IMP neurological system process
GO:0050890 IMP cognition
GO:0051291 IEA protein heterooligomerization
GO:0051899 ISS membrane depolarization
GO:0051963 ISS regulation of synapse assembly
GO:0060084 ISS synaptic transmission involved in micturition
GO:0098655 IEA cation transmembrane transport

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000029562 Chrnb2-201 protein_coding Mus_musculus 0 1779
ENSMUST00000034854 Chrnb4-201 protein_coding Mus_musculus 0 582
ENSDART00000079613 chrna2b-201 protein_coding Danio_rerio 5e-33 148
ENSDART00000136317 chrna2b-001 protein_coding Danio_rerio 5e-33 148
ENSDART00000033947 chrna2a-001 protein_coding Danio_rerio 8e-26 124

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