C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000029562 Chrnb2-201 ENSMUSG00000027950 10090 - 3:89753448-89764632 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000029562
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000029562 0.306±0.15 2.078±0.20 0.359±0.17 17.658±6.23 0.924±0.10 1.097±0.18 0.166±0.02 0.559±0.11 0.242±0.15 0.312±0.15 0.058±0.03 0.477±0.17 0.063±0.02 1.464±0.72

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001508 IMP action potential
GO:0001661 IMP conditioned taste aversion
GO:0001666 IMP response to hypoxia
GO:0004889 IMP acetylcholine-activated cation-selective channel activity
GO:0005515 IPI protein binding
GO:0005886 IDA plasma membrane
GO:0005892 IDA acetylcholine-gated channel complex
GO:0006816 IGI calcium ion transport
GO:0006939 IGI smooth muscle contraction
GO:0007165 IEA signal transduction
GO:0007271 IEA synaptic transmission, cholinergic
GO:0007601 IMP visual perception
GO:0007605 IMP sensory perception of sound
GO:0007612 IMP learning
GO:0007613 IMP memory
GO:0007626 IMP locomotory behavior
GO:0008144 IEA drug binding
GO:0008306 IGI associative learning
GO:0008542 IMP visual learning
GO:0009897 IDA external side of plasma membrane
GO:0014059 IMP regulation of dopamine secretion
GO:0015464 IEA acetylcholine receptor activity
GO:0019233 IMP sensory perception of pain
GO:0021562 IMP vestibulocochlear nerve development
GO:0021631 IMP optic nerve morphogenesis
GO:0021771 IMP lateral geniculate nucleus development
GO:0021952 IMP central nervous system projection neuron axonogenesis
GO:0021955 IMP central nervous system neuron axonogenesis
GO:0030054 IEA cell junction
GO:0030890 IC positive regulation of B cell proliferation
GO:0032225 IMP regulation of synaptic transmission, dopaminergic
GO:0032226 IMP positive regulation of synaptic transmission, dopaminergic
GO:0033603 IMP positive regulation of dopamine secretion
GO:0035094 IMP response to nicotine
GO:0035095 IMP behavioral response to nicotine
GO:0035176 IMP social behavior
GO:0042053 IMP regulation of dopamine metabolic process
GO:0042113 IMP B cell activation
GO:0042166 IEA acetylcholine binding
GO:0042220 IMP response to cocaine
GO:0042320 IMP regulation of circadian sleep/wake cycle, REM sleep
GO:0042391 IGI regulation of membrane potential
GO:0045188 IMP regulation of circadian sleep/wake cycle, non-REM sleep
GO:0045211 IEA postsynaptic membrane
GO:0045471 IMP response to ethanol
GO:0045759 IMP negative regulation of action potential
GO:0046982 IEA protein heterodimerization activity
GO:0048814 IMP regulation of dendrite morphogenesis
GO:0050877 IEA neurological system process
GO:0050890 IEA cognition
GO:0051291 IEA protein heterooligomerization
GO:0051899 IMP membrane depolarization
GO:0051963 IMP regulation of synapse assembly
GO:0060084 IGI synaptic transmission involved in micturition
GO:0098655 IEA cation transmembrane transport

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000079613 chrna2b-201 protein_coding Danio_rerio 2e-36 159
ENSDART00000136317 chrna2b-001 protein_coding Danio_rerio 2e-36 159
ENSDART00000033947 chrna2a-001 protein_coding Danio_rerio 3e-30 139
ENST00000240132 CHRNA2-004 protein_coding Homo_sapiens 0 226
ENST00000261751 CHRNB4-001 protein_coding Homo_sapiens 0 616
ENST00000326828 CHRNA3-001 protein_coding Homo_sapiens 2e-35 156
ENST00000348639 CHRNA3-002 protein_coding Homo_sapiens 1e-35 156
ENST00000368476 CHRNB2-001 protein_coding Homo_sapiens 0 1779
ENST00000370263 CHRNA4-001 protein_coding Homo_sapiens 0 239
ENST00000407991 CHRNA2-201 protein_coding Homo_sapiens 0 226
ENST00000463705 CHRNA4-002 processed_transcript Homo_sapiens 0 239
ENST00000467563 CHRNA4-004 processed_transcript Homo_sapiens 0 239
ENST00000498043 CHRNA4-007 nonsense_mediated_decay Homo_sapiens 0 239
ENST00000520933 CHRNA2-001 protein_coding Homo_sapiens 0 226
ENST00000523529 CHRNA2-006 retained_intron Homo_sapiens 0 226
ENST00000523695 CHRNA2-005 nonsense_mediated_decay Homo_sapiens 0 226
ENST00000558903 CHRNA3-008 processed_transcript Homo_sapiens 6e-23 111
ENST00000559658 CHRNA3-003 nonsense_mediated_decay Homo_sapiens 9e-36 156
ENST00000559849 CHRNB4-002 nonsense_mediated_decay Homo_sapiens 0 501
ENST00000615287 CHRNA4-201 protein_coding Homo_sapiens 0 239

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