C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: protein tyrosine phosphatase, non-receptor type 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000371621 PTPN1-001 ENSG00000196396 9606 + 20:50510354-50585241 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000371621
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000371621 3.510±0.00 3.835±0.00 1.717±0.39 2.988±1.44 2.988±1.76 2.617±0.00 1.675±0.00 1.840±0.78 3.926±0.00 0.684±0.11 3.753±1.76 4.799±1.42 2.256±0.08

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007ZW CIL_0007ZW_0001 VISTA 20:50090256-50696209
CIL_0007H3 CIL_0007H3_0001 CGP 20:50190734-50585241
CIL_0007VZ CIL_0007VZ_0001 VISTA 20:50389770-50992625
CIL_0007GS CIL_0007GS_0001 CGP 20:50510321-50691528

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004725 IEA:IDA protein tyrosine phosphatase activity
GO:0005158 IEA insulin receptor binding
GO:0005515 IPI protein binding
GO:0005769 IDA early endosome
GO:0005783 IDA endoplasmic reticulum
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006470 IEA protein dephosphorylation
GO:0007596 TAS blood coagulation
GO:0008270 IDA zinc ion binding
GO:0008286 IEA insulin receptor signaling pathway
GO:0009966 IMP regulation of signal transduction
GO:0016311 IEA dephosphorylation
GO:0016791 IEA phosphatase activity
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019899 IPI enzyme binding
GO:0019901 IPI protein kinase binding
GO:0030100 IDA regulation of endocytosis
GO:0030168 TAS platelet activation
GO:0030948 ISS negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0030968 IDA endoplasmic reticulum unfolded protein response
GO:0030971 IPI receptor tyrosine kinase binding
GO:0031410 IEA cytoplasmic vesicle
GO:0031532 IMP actin cytoskeleton reorganization
GO:0035335 IMP peptidyl-tyrosine dephosphorylation
GO:0035791 IMP platelet-derived growth factor receptor-beta signaling pathway
GO:0044822 IDA poly(A) RNA binding
GO:0046626 IEA regulation of insulin receptor signaling pathway
GO:0046627 NAS negative regulation of insulin receptor signaling pathway
GO:0046875 IPI ephrin receptor binding
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0060334 TAS regulation of interferon-gamma-mediated signaling pathway
GO:0060337 TAS type I interferon signaling pathway
GO:0060338 TAS regulation of type I interferon-mediated signaling pathway
GO:0060397 TAS JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070373 ISS negative regulation of ERK1 and ERK2 cascade
GO:0097443 ISS sorting endosome
GO:1902202 IMP regulation of hepatocyte growth factor receptor signaling pathway
GO:1990264 ISS peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000029053 Ptpn1-001 protein_coding Mus_musculus 0 1162
ENSMUST00000126839 Ptpn1-002 processed_transcript Mus_musculus 0 1053

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