C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: activin A receptor type II-like 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000388922 ACVRL1-001 ENSG00000139567 9606 + 12:51907418-51921069 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBreastColonHeartLiverLungMuscleOvaryPlacentaTestisENST00000388922
Transcript ID Adipose Adrenal Bladder Breast Colon Heart Liver Lung Muscle Ovary Placenta Testis
ENST00000388922 30.989±0.00 14.489±0.00 1.446±0.00 13.612±0.00 8.420±4.61 2.589±1.49 0.715±0.00 67.456±0.00 3.072±0.00 3.331±1.27 37.787±11.24 2.161±1.89

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006JX CIL_0006JX_0001 CGP 12:51887960-51923361
CIL_0006JY CIL_0006JY_0001 CGP 12:51906908-51997078

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001525 IMP angiogenesis
GO:0001701 IEA in utero embryonic development
GO:0001936 TAS regulation of endothelial cell proliferation
GO:0001937 IEA negative regulation of endothelial cell proliferation
GO:0001938 IEA positive regulation of endothelial cell proliferation
GO:0001946 ISS lymphangiogenesis
GO:0001955 TAS blood vessel maturation
GO:0001974 ISS blood vessel remodeling
GO:0002043 TAS blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004675 NAS:IEA transmembrane receptor protein serine/threonine kinase activity
GO:0004702 IEA receptor signaling protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005024 IDA transforming growth factor beta-activated receptor activity
GO:0005025 IDA transforming growth factor beta receptor activity, type I
GO:0005515 IPI protein binding
GO:0005524 IEA:IDA ATP binding
GO:0005887 IDA integral component of plasma membrane
GO:0006275 TAS regulation of DNA replication
GO:0006355 IMP regulation of transcription, DNA-templated
GO:0006468 IDA:IEA protein phosphorylation
GO:0007162 IMP negative regulation of cell adhesion
GO:0007165 IDA signal transduction
GO:0007179 IDA transforming growth factor beta receptor signaling pathway
GO:0008015 IMP blood circulation
GO:0008217 IMP regulation of blood pressure
GO:0008285 IMP negative regulation of cell proliferation
GO:0009986 IDA cell surface
GO:0010596 IDA negative regulation of endothelial cell migration
GO:0010862 IMP positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016020 IEA membrane
GO:0016361 IDA activin receptor activity, type I
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019901 IPI protein kinase binding
GO:0030308 IDA negative regulation of cell growth
GO:0030336 IMP negative regulation of cell migration
GO:0030425 IEA dendrite
GO:0030509 IMP BMP signaling pathway
GO:0030513 IDA positive regulation of BMP signaling pathway
GO:0032332 TAS positive regulation of chondrocyte differentiation
GO:0032924 IDA activin receptor signaling pathway
GO:0035313 IMP wound healing, spreading of epidermal cells
GO:0043025 IEA neuronal cell body
GO:0043535 TAS regulation of blood vessel endothelial cell migration
GO:0043537 IMP negative regulation of blood vessel endothelial cell migration
GO:0045602 IEA negative regulation of endothelial cell differentiation
GO:0045603 IEA positive regulation of endothelial cell differentiation
GO:0045766 IEA positive regulation of angiogenesis
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046332 IDA SMAD binding
GO:0046872 IEA metal ion binding
GO:0048185 IDA activin binding
GO:0048514 IEA blood vessel morphogenesis
GO:0050431 IPI transforming growth factor beta binding
GO:0051291 IEA protein heterooligomerization
GO:0051895 IMP negative regulation of focal adhesion assembly
GO:0060836 IMP lymphatic endothelial cell differentiation
GO:0060840 ISS artery development
GO:0060841 ISS venous blood vessel development
GO:0061154 IMP endothelial tube morphogenesis
GO:0061298 ISS retina vasculature development in camera-type eye
GO:0071560 IDA cellular response to transforming growth factor beta stimulus
GO:0071773 IMP cellular response to BMP stimulus
GO:2000279 IMP negative regulation of DNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000120754 Acvrl1-006 protein_coding Mus_musculus 0 1574
ENSMUST00000121718 Acvrl1-004 protein_coding Mus_musculus 0 1574
ENSMUST00000119063 Acvrl1-003 protein_coding Mus_musculus 0 1574
ENSMUST00000117984 Acvrl1-005 protein_coding Mus_musculus 0 1574
ENSMUST00000120028 Acvrl1-002 protein_coding Mus_musculus 0 1574
ENSMUST00000000542 Acvrl1-001 protein_coding Mus_musculus 0 1574
ENSMUST00000128525 Acvrl1-011 processed_transcript Mus_musculus 0 460

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