C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: MDM2 proto-oncogene, E3 ubiquitin protein ligase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000393413 MDM2-032 ENSG00000135679 9606 + 12:68809212-68839849 protein_coding

Expression Patterns

No expression data.

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002KM CIL_0002KM_0002 CGP 12:68746106-68850686

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0002039 IPI p53 binding
GO:0004842 IMP ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 IDA nucleoplasm
GO:0005730 IDA nucleolus
GO:0005737 IMP cytoplasm
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006461 IDA protein complex assembly
GO:0006977 IMP DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007268 TAS synaptic transmission
GO:0008270 IDA:IEA zinc ion binding
GO:0008284 TAS positive regulation of cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0016032 IEA viral process
GO:0016567 IDA protein ubiquitination
GO:0016604 IDA nuclear body
GO:0016874 IEA ligase activity
GO:0018205 IMP peptidyl-lysine modification
GO:0019899 IPI enzyme binding
GO:0030666 TAS endocytic vesicle membrane
GO:0031625 IPI ubiquitin protein ligase binding
GO:0031648 IDA protein destabilization
GO:0032436 IDA positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504 IDA protein localization to nucleus
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042176 IDA regulation of protein catabolic process
GO:0042787 IDA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042802 IPI identical protein binding
GO:0043066 IEA negative regulation of apoptotic process
GO:0043234 IDA protein complex
GO:0043518 IDA negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045087 TAS innate immune response
GO:0045184 IDA establishment of protein localization
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045931 IMP positive regulation of mitotic cell cycle
GO:0046677 IEP response to antibiotic
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0071157 IDA:IEA negative regulation of cell cycle arrest
GO:0071456 IEP cellular response to hypoxia

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000132277 Mdm2-004 retained_intron Mus_musculus 2e-23 113
ENSMUST00000155285 Mdm2-003 nonsense_mediated_decay Mus_musculus 2e-23 113
ENSMUST00000105263 Mdm2-002 protein_coding Mus_musculus 2e-23 113
ENSMUST00000020408 Mdm2-001 protein_coding Mus_musculus 2e-23 113

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