C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: mediator complex subunit 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000394287 MED1-002 ENSG00000125686 9606 - 17:39404285-39451268 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainBreastLiverLungOvaryTestisENST00000394287
Transcript ID Bladder Brain Breast Liver Lung Ovary Testis
ENST00000394287 1.156±0.00 1.145±0.00 2.248±0.00 2.529±0.00 1.355±0.00 3.238±0.00 1.450±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008SN CIL_0008SN_0001 VISTA 17:39110111-39710718
CIL_0007D6 CIL_0007D6_0001 CGP 17:39252644-39451286
CIL_00080Z CIL_00080Z_0001 VISTA 17:39318232-39918735
CIL_00098W CIL_00098W_0001 VISTA 17:39359510-39962707
CIL_0007WH CIL_0007WH_0001 VISTA 17:39374871-39978277
CIL_0007D3 CIL_0007D3_0001 CGP 17:39404285-39564907

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000902 IMP cell morphogenesis
GO:0000981 ISS sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001047 IDA core promoter binding
GO:0001104 IDA:IEA RNA polymerase II transcription cofactor activity
GO:0001525 ISS angiogenesis
GO:0002088 ISS lens development in camera-type eye
GO:0002154 IMP thyroid hormone mediated signaling pathway
GO:0003682 IMP chromatin binding
GO:0003712 IDA transcription cofactor activity
GO:0003713 IDA transcription coactivator activity
GO:0004872 IDA receptor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005730 IDA nucleolus
GO:0006356 IDA regulation of transcription from RNA polymerase I promoter
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006367 IDA transcription initiation from RNA polymerase II promoter
GO:0006702 IMP androgen biosynthetic process
GO:0008134 IPI transcription factor binding
GO:0010467 TAS gene expression
GO:0010628 IMP positive regulation of gene expression
GO:0010839 IMP negative regulation of keratinocyte proliferation
GO:0016020 IDA membrane
GO:0016592 IDA:IEA mediator complex
GO:0016922 IDA ligand-dependent nuclear receptor binding
GO:0030216 IMP keratinocyte differentiation
GO:0030331 IPI estrogen receptor binding
GO:0030374 NAS ligand-dependent nuclear receptor transcription coactivator activity
GO:0030375 IMP thyroid hormone receptor coactivator activity
GO:0030518 IDA intracellular steroid hormone receptor signaling pathway
GO:0030521 IDA androgen receptor signaling pathway
GO:0035257 IPI nuclear hormone receptor binding
GO:0035855 ISS megakaryocyte development
GO:0036033 IDA mediator complex binding
GO:0042789 ISS mRNA transcription from RNA polymerase II promoter
GO:0042809 NAS vitamin D receptor binding
GO:0042974 IPI retinoic acid receptor binding
GO:0042975 IPI peroxisome proliferator activated receptor binding
GO:0043066 ISS negative regulation of apoptotic process
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045444 IDA fat cell differentiation
GO:0045618 IMP positive regulation of keratinocyte differentiation
GO:0045665 ISS negative regulation of neuron differentiation
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046966 IDA thyroid hormone receptor binding
GO:0048821 ISS erythrocyte development
GO:0050693 IPI LBD domain binding
GO:0051726 NAS regulation of cell cycle
GO:0070371 IDA ERK1 and ERK2 cascade
GO:0071364 IDA cellular response to epidermal growth factor stimulus
GO:0071383 IDA cellular response to steroid hormone stimulus
GO:0097067 IDA cellular response to thyroid hormone stimulus
GO:2000273 IMP positive regulation of receptor activity
GO:2001141 IMP regulation of RNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000107545 Med1-001 protein_coding Mus_musculus 0 2479
ENSMUST00000092735 Med1-004 protein_coding Mus_musculus 0 2425
ENSMUST00000018304 Med1-002 protein_coding Mus_musculus 0 2274
ENSMUST00000129557 Med1-003 processed_transcript Mus_musculus 0 1110
ENSMUST00000126483 Med1-006 processed_transcript Mus_musculus 0 909
ENSMUST00000135479 Med1-005 processed_transcript Mus_musculus 0 442
ENSMUST00000147933 Med1-007 processed_transcript Mus_musculus 0 359

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