C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000450295 SEMA4D-018 ENSG00000187764 9606 - 9:89376386-89418833 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBreastENST00000450295
Transcript ID Bladder Breast
ENST00000450295 0.572±0.00 0.708±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006BJ CIL_0006BJ_0001 CGP 9:89360787-89606555

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0004872 IDA:IEA receptor activity
GO:0004888 IMP transmembrane signaling receptor activity
GO:0005102 IDA receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005615 ISS extracellular space
GO:0005886 TAS plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006955 TAS immune response
GO:0007155 TAS cell adhesion
GO:0007162 IDA negative regulation of cell adhesion
GO:0007275 IEA multicellular organismal development
GO:0007411 TAS axon guidance
GO:0008360 IMP regulation of cell shape
GO:0010693 IMP negative regulation of alkaline phosphatase activity
GO:0014068 IMP positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 IEA membrane
GO:0030215 ISS semaphorin receptor binding
GO:0030335 ISS positive regulation of cell migration
GO:0031344 IMP regulation of cell projection organization
GO:0032321 ISS positive regulation of Rho GTPase activity
GO:0043066 TAS negative regulation of apoptotic process
GO:0043931 IMP ossification involved in bone maturation
GO:0045668 ISS negative regulation of osteoblast differentiation
GO:0048672 IMP positive regulation of collateral sprouting
GO:0048814 IMP regulation of dendrite morphogenesis
GO:0050731 ISS positive regulation of peptidyl-tyrosine phosphorylation
GO:0050732 ISS negative regulation of peptidyl-tyrosine phosphorylation
GO:0050772 IEA positive regulation of axonogenesis
GO:0070486 IMP leukocyte aggregation
GO:0071526 IDA semaphorin-plexin signaling pathway
GO:1900220 ISS semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000110039 Sema4d-003 protein_coding Mus_musculus 0 2340
ENSMUST00000021900 Sema4d-002 protein_coding Mus_musculus 0 2340
ENSMUST00000110040 Sema4d-001 protein_coding Mus_musculus 0 2340
ENSMUST00000110042 Gm15440-001 protein_coding Mus_musculus 4e-24 119

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