C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: breast cancer 1, early onset
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000461798 BRCA1-020 ENSG00000012048 9606 - 17:43099831-43125370 nonsense_mediated_decay

Expression Patterns

No expression data.

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00061F CIL_00061F_0001 CGP 17:43025241-43125483
CIL_00040M CIL_00040M_0001 CGP 17:43044295-43211689

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000151 NAS ubiquitin ligase complex
GO:0000724 IDA double-strand break repair via homologous recombination
GO:0003677 TAS DNA binding
GO:0003713 NAS transcription coactivator activity
GO:0003723 IDA RNA binding
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005694 ISS chromosome
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0006281 TAS DNA repair
GO:0006301 IDA postreplication repair
GO:0006302 IMP double-strand break repair
GO:0006357 TAS regulation of transcription from RNA polymerase II promoter
GO:0006359 TAS regulation of transcription from RNA polymerase III promoter
GO:0006633 IEA fatty acid biosynthetic process
GO:0006915 TAS apoptotic process
GO:0006974 TAS cellular response to DNA damage stimulus
GO:0006978 TAS DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007059 IMP chromosome segregation
GO:0008270 IEA zinc ion binding
GO:0008274 NAS gamma-tubulin ring complex
GO:0008630 IDA intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010212 IMP response to ionizing radiation
GO:0010575 IMP positive regulation vascular endothelial growth factor production
GO:0010628 IMP positive regulation of gene expression
GO:0015631 NAS tubulin binding
GO:0016567 IDA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0019899 IPI enzyme binding
GO:0030521 NAS androgen receptor signaling pathway
GO:0030529 IDA ribonucleoprotein complex
GO:0031398 IDA positive regulation of protein ubiquitination
GO:0031436 IDA BRCA1-BARD1 complex
GO:0031572 IMP G2 DNA damage checkpoint
GO:0031625 IPI ubiquitin protein ligase binding
GO:0035066 IDA positive regulation of histone acetylation
GO:0042127 TAS regulation of cell proliferation
GO:0042981 TAS regulation of apoptotic process
GO:0043234 IDA protein complex
GO:0043627 IDA response to estrogen
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045717 IMP negative regulation of fatty acid biosynthetic process
GO:0045739 IMP positive regulation of DNA repair
GO:0045766 IMP positive regulation of angiogenesis
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 TAS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046600 NAS negative regulation of centriole replication
GO:0046872 IEA metal ion binding
GO:0050681 NAS androgen receptor binding
GO:0051571 IDA positive regulation of histone H3-K4 methylation
GO:0051573 IDA negative regulation of histone H3-K9 methylation
GO:0051865 IDA protein autoubiquitination
GO:0070512 IDA positive regulation of histone H4-K20 methylation
GO:0070531 IDA BRCA1-A complex
GO:0071158 IDA positive regulation of cell cycle arrest
GO:0071356 IMP cellular response to tumor necrosis factor
GO:0071681 IDA cellular response to indole-3-methanol
GO:0085020 IDA protein K6-linked ubiquitination
GO:1902042 IMP negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000378 IMP negative regulation of reactive oxygen species metabolic process
GO:2000617 IDA positive regulation of histone H3-K9 acetylation
GO:2000620 IDA positive regulation of histone H4-K16 acetylation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000017290 Brca1-001 protein_coding Mus_musculus 0 285
ENSMUST00000142086 Brca1-002 nonsense_mediated_decay Mus_musculus 0 268
ENSMUST00000190862 Brca1-005 protein_coding Mus_musculus 8e-37 158

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