C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: LYN proto-oncogene, Src family tyrosine kinase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000519728 LYN-002 ENSG00000254087 9606 + 8:55879813-56010572 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastHeartKidneyLungMuscleOvaryTestisENST00000519728
Transcript ID Adipose Bladder Brain Breast Heart Kidney Lung Muscle Ovary Testis
ENST00000519728 3.347±0.00 1.710±0.00 1.299±0.78 4.273±0.00 0.388±0.00 0.988±0.00 5.104±0.00 0.053±0.00 2.388±0.47 0.375±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00009D CIL_00009D_0001 CGP 8:55773142-56011381
CIL_0001U6 CIL_0001U6_0001 CGP 8:55879813-56074581

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001782 ISS B cell homeostasis
GO:0001817 ISS regulation of cytokine production
GO:0001932 TAS regulation of protein phosphorylation
GO:0001933 ISS negative regulation of protein phosphorylation
GO:0002431 ISS Fc receptor mediated stimulatory signaling pathway
GO:0002513 ISS tolerance induction to self antigen
GO:0002553 IEA histamine secretion by mast cell
GO:0002576 ISS platelet degranulation
GO:0002762 IEA negative regulation of myeloid leukocyte differentiation
GO:0002768 ISS immune response-regulating cell surface receptor signaling pathway
GO:0002774 ISS Fc receptor mediated inhibitory signaling pathway
GO:0002902 IEA regulation of B cell apoptotic process
GO:0004672 IEA protein kinase activity
GO:0004713 IDA:IEA protein tyrosine kinase activity
GO:0004715 TAS non-membrane spanning protein tyrosine kinase activity
GO:0004716 TAS receptor signaling protein tyrosine kinase activity
GO:0005102 IEA receptor binding
GO:0005161 IEA platelet-derived growth factor receptor binding
GO:0005178 IEA integrin binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005758 IEA mitochondrial intermembrane space
GO:0005794 IDA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006468 IDA:IEA protein phosphorylation
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0006991 IEA response to sterol depletion
GO:0007165 TAS signal transduction
GO:0007169 IMP transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007596 TAS blood coagulation
GO:0008284 ISS positive regulation of cell proliferation
GO:0008285 IMP negative regulation of cell proliferation
GO:0009636 IEA response to toxic substance
GO:0009725 ISS response to hormone
GO:0009743 IEA response to carbohydrate
GO:0010976 IMP positive regulation of neuron projection development
GO:0014003 IEA oligodendrocyte development
GO:0014069 IEA postsynaptic density
GO:0014070 IEA response to organic cyclic compound
GO:0016020 IEA membrane
GO:0016032 IEA viral process
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017124 IEA SH3 domain binding
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019899 IPI enzyme binding
GO:0023014 TAS signal transduction by phosphorylation
GO:0030061 IEA mitochondrial crista
GO:0030097 IEA hemopoiesis
GO:0030168 TAS platelet activation
GO:0030218 ISS erythrocyte differentiation
GO:0030335 IEA positive regulation of cell migration
GO:0030889 IEA negative regulation of B cell proliferation
GO:0031175 IEA neuron projection development
GO:0031295 TAS T cell costimulation
GO:0031625 IEA ubiquitin protein ligase binding
GO:0031663 ISS lipopolysaccharide-mediated signaling pathway
GO:0031668 IEA cellular response to extracellular stimulus
GO:0031966 IEA mitochondrial membrane
GO:0032403 IEA protein complex binding
GO:0032868 IEA response to insulin
GO:0033003 ISS regulation of mast cell activation
GO:0033628 IMP regulation of cell adhesion mediated by integrin
GO:0034136 ISS negative regulation of toll-like receptor 2 signaling pathway
GO:0034144 ISS negative regulation of toll-like receptor 4 signaling pathway
GO:0034605 IEA cellular response to heat
GO:0034666 IEA integrin alpha2-beta1 complex
GO:0035556 IEA intracellular signal transduction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042327 IEA positive regulation of phosphorylation
GO:0042493 IEA response to drug
GO:0042531 ISS positive regulation of tyrosine phosphorylation of STAT protein
GO:0042629 IEA mast cell granule
GO:0043200 IEA response to amino acid
GO:0043208 IEA glycosphingolipid binding
GO:0043304 ISS regulation of mast cell degranulation
GO:0043407 ISS negative regulation of MAP kinase activity
GO:0043434 IEA response to peptide hormone
GO:0043552 IEA positive regulation of phosphatidylinositol 3-kinase activity
GO:0044325 IPI ion channel binding
GO:0045087 TAS innate immune response
GO:0045121 IDA membrane raft
GO:0045646 ISS regulation of erythrocyte differentiation
GO:0046777 IDA protein autophosphorylation
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048678 IEA response to axon injury
GO:0050663 IEA cytokine secretion
GO:0050707 IEA regulation of cytokine secretion
GO:0050727 IEA regulation of inflammatory response
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050777 TAS negative regulation of immune response
GO:0050853 IEA B cell receptor signaling pathway
GO:0050855 ISS regulation of B cell receptor signaling pathway
GO:0050861 IEA positive regulation of B cell receptor signaling pathway
GO:0050900 TAS leukocyte migration
GO:0051219 IEA phosphoprotein binding
GO:0051272 IDA positive regulation of cellular component movement
GO:0051279 IEA regulation of release of sequestered calcium ion into cytosol
GO:0060252 IEA positive regulation of glial cell proliferation
GO:0060369 IEA positive regulation of Fc receptor mediated stimulatory signaling pathway
GO:0060397 TAS JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070062 IDA extracellular vesicular exosome
GO:0070304 IDA positive regulation of stress-activated protein kinase signaling cascade
GO:0070372 ISS regulation of ERK1 and ERK2 cascade
GO:0070373 ISS negative regulation of ERK1 and ERK2 cascade
GO:0070447 IEA positive regulation of oligodendrocyte progenitor proliferation
GO:0070667 ISS negative regulation of mast cell proliferation
GO:0070668 IMP positive regulation of mast cell proliferation
GO:0071300 IMP cellular response to retinoic acid
GO:0090025 IMP regulation of monocyte chemotaxis
GO:0090330 ISS regulation of platelet aggregation
GO:0097028 ISS dendritic cell differentiation
GO:1902532 ISS negative regulation of intracellular signal transduction
GO:2000670 ISS positive regulation of dendritic cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000041377 Lyn-001 protein_coding Mus_musculus 0 1975
ENSMUST00000103010 Lyn-002 protein_coding Mus_musculus 0 1725
ENSMUST00000121996 Gm11787-001 unprocessed_pseudogene Mus_musculus 0 1280
ENSMUST00000145083 Lyn-003 processed_transcript Mus_musculus 0 259
ENSDART00000082356 lck-201 protein_coding Danio_rerio 0 204
ENSDART00000105478 lck-202 protein_coding Danio_rerio 0 204
ENSDART00000148860 lck-001 protein_coding Danio_rerio 0 204
ENSDART00000126663 lck-002 protein_coding Danio_rerio 0 204

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