C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000520810 IKBKB-002 ENSG00000104365 9606 + 8:42271302-42331608 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; HeartLiverLungMuscleOvaryPlacentaENST00000520810
Transcript ID Heart Liver Lung Muscle Ovary Placenta
ENST00000520810 0.319±0.00 1.886±0.00 4.519±0.00 4.118±0.00 4.236±0.00 2.534±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007IG CIL_0007IG_0002 CGP 8:42175233-42332653

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001782 IEA B cell homeostasis
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IDA:IEA protein kinase activity
GO:0004674 TAS protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006468 IDA:IEA protein phosphorylation
GO:0006954 TAS inflammatory response
GO:0007249 TAS I-kappaB kinase/NF-kappaB signaling
GO:0007252 IEA I-kappaB phosphorylation
GO:0008384 TAS:IEA IkappaB kinase activity
GO:0008385 TAS IkappaB kinase complex
GO:0009103 IEA lipopolysaccharide biosynthetic process
GO:0009615 TAS response to virus
GO:0009898 ISS cytoplasmic side of plasma membrane
GO:0010765 IEA positive regulation of sodium ion transport
GO:0016020 IEA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0019901 IPI protein kinase binding
GO:0032481 TAS positive regulation of type I interferon production
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035631 ISS CD40 receptor complex
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042501 IDA serine phosphorylation of STAT protein
GO:0042803 IDA protein homodimerization activity
GO:0043066 TAS negative regulation of apoptotic process
GO:0043123 TAS positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 TAS innate immune response
GO:0045893 NAS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IDA protein heterodimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0050852 TAS T cell receptor signaling pathway
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0070423 TAS nucleotide-binding oligomerization domain containing signaling pathway
GO:0071356 IDA cellular response to tumor necrosis factor
GO:0097110 IDA scaffold protein binding
GO:2001259 IEA positive regulation of cation channel activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000033939 Ikbkb-001 protein_coding Mus_musculus 0 2601
ENSMUST00000125314 Ikbkb-002 nonsense_mediated_decay Mus_musculus 0 2573
ENSMUST00000063401 Ikbkb-011 protein_coding Mus_musculus 0 2556
ENSMUST00000135326 Ikbkb-003 nonsense_mediated_decay Mus_musculus 0 2187
ENSMUST00000146212 Ikbkb-010 retained_intron Mus_musculus 0 1526
ENSMUST00000150259 Ikbkb-009 retained_intron Mus_musculus 0 909
ENSMUST00000144583 Ikbkb-008 retained_intron Mus_musculus 0 723
ENSMUST00000144895 Ikbkb-007 retained_intron Mus_musculus 0 492
ENSMUST00000126439 Ikbkb-006 retained_intron Mus_musculus 0 414
ENSMUST00000131767 Ikbkb-014 protein_coding Mus_musculus 0 315

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