C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: protein tyrosine kinase 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000521059 PTK2-057 ENSG00000169398 9606 - 8:140658402-141001196 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeColonHeartLungMuscleOvaryPlacentaTestisENST00000521059
Transcript ID Adipose Colon Heart Lung Muscle Ovary Placenta Testis
ENST00000521059 3.634±0.00 6.687±0.00 3.089±0.00 3.706±0.00 1.423±0.85 10.929±1.64 9.366±4.66 8.686±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002XD CIL_0002XD_0001 CGP 8:140531165-141002216
CIL_0006FQ CIL_0006FQ_0002 CGP 8:140657900-141195808

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001525 TAS angiogenesis
GO:0001725 IDA stress fiber
GO:0001890 TAS placenta development
GO:0001934 IMP positive regulation of protein phosphorylation
GO:0003007 TAS heart morphogenesis
GO:0003779 IDA actin binding
GO:0004672 TAS:IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004715 IDA non-membrane spanning protein tyrosine kinase activity
GO:0004871 IEA signal transducer activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005829 IDA cytosol
GO:0005856 IEA:TAS cytoskeleton
GO:0005925 IEA:IDA focal adhesion
GO:0006468 IEA protein phosphorylation
GO:0006915 TAS apoptotic process
GO:0006921 TAS cellular component disassembly involved in execution phase of apoptosis
GO:0007165 IEA signal transduction
GO:0007172 IEA signal complex assembly
GO:0007179 IDA transforming growth factor beta receptor signaling pathway
GO:0007229 IMP integrin-mediated signaling pathway
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0008284 ISS positive regulation of cell proliferation
GO:0008360 IMP regulation of cell shape
GO:0008432 IDA JUN kinase binding
GO:0009790 TAS embryo development
GO:0010594 TAS regulation of endothelial cell migration
GO:0014068 IMP positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA:IDA peptidyl-tyrosine phosphorylation
GO:0019901 IPI protein kinase binding
GO:0022408 IDA negative regulation of cell-cell adhesion
GO:0030010 TAS establishment of cell polarity
GO:0030168 TAS platelet activation
GO:0030335 IDA positive regulation of cell migration
GO:0032319 TAS regulation of Rho GTPase activity
GO:0033628 IDA regulation of cell adhesion mediated by integrin
GO:0038007 TAS netrin-activated signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042127 IMP regulation of cell proliferation
GO:0042169 IPI SH2 domain binding
GO:0043066 IMP negative regulation of apoptotic process
GO:0043552 TAS positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 TAS innate immune response
GO:0045667 IMP regulation of osteoblast differentiation
GO:0045860 IMP positive regulation of protein kinase activity
GO:0046777 IDA protein autophosphorylation
GO:0048013 IDA ephrin receptor signaling pathway
GO:0048870 TAS cell motility
GO:0051493 TAS regulation of cytoskeleton organization
GO:0051893 TAS regulation of focal adhesion assembly
GO:0051897 IMP positive regulation of protein kinase B signaling
GO:0060396 IDA growth hormone receptor signaling pathway
GO:2000060 ISS positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000811 IMP negative regulation of anoikis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000110036 Ptk2-201 protein_coding Mus_musculus 0 4344
ENSMUST00000170939 Ptk2-202 protein_coding Mus_musculus 0 3747
ENSDART00000142779 ptk2.2-002 protein_coding Danio_rerio 0 202

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