C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: FYVE, RhoGEF and PH domain containing 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000525053 FGD4-011 ENSG00000139132 9606 + 12:32534324-32640737 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainKidneyLiverOvaryENST00000525053
Transcript ID Brain Kidney Liver Ovary
ENST00000525053 1.987±0.00 3.634±0.00 1.140±0.00 3.043±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003DJ CIL_0003DJ_0002 CGP 12:32106835-32646050

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001726 ISS ruffle
GO:0003779 IEA actin binding
GO:0005085 ISS guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005737 ISS cytoplasm
GO:0005794 ISS Golgi apparatus
GO:0005829 TAS cytosol
GO:0007010 ISS cytoskeleton organization
GO:0007264 TAS small GTPase mediated signal transduction
GO:0008360 ISS regulation of cell shape
GO:0015629 IDA actin cytoskeleton
GO:0030027 ISS lamellipodium
GO:0030036 ISS actin cytoskeleton organization
GO:0031267 ISS small GTPase binding
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0043065 TAS positive regulation of apoptotic process
GO:0043088 ISS regulation of Cdc42 GTPase activity
GO:0043547 ISS positive regulation of GTPase activity
GO:0046847 ISS filopodium assembly
GO:0046872 IEA metal ion binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000161861 Fgd4-001 protein_coding Mus_musculus 0 2667
ENSMUST00000162671 Fgd4-008 protein_coding Mus_musculus 0 2608
ENSMUST00000069284 Fgd4-006 protein_coding Mus_musculus 0 2584
ENSMUST00000161188 Fgd4-201 protein_coding Mus_musculus 0 1973
ENSMUST00000172181 Fgd4-002 protein_coding Mus_musculus 0 1973
ENSMUST00000162045 Fgd4-003 protein_coding Mus_musculus 0 1679
ENSMUST00000162124 Fgd4-004 protein_coding Mus_musculus 0 1434
ENSMUST00000159542 Fgd4-010 protein_coding Mus_musculus 0 1219
ENSMUST00000159058 Fgd4-005 retained_intron Mus_musculus 0 933
ENSMUST00000162542 Fgd4-011 retained_intron Mus_musculus 0 464
ENSMUST00000162414 Fgd4-007 retained_intron Mus_musculus 0 464
ENSMUST00000161624 Fgd4-009 retained_intron Mus_musculus 0 261

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