C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: FYVE, RhoGEF and PH domain containing 6
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000546711 FGD6-004 ENSG00000180263 9606 - 12:95085543-95217464 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastColonHeartLiverOvaryENST00000546711
Transcript ID Adrenal Brain Breast Colon Heart Liver Ovary
ENST00000546711 0.407±0.00 0.437±0.17 0.432±0.21 0.722±0.00 0.590±0.00 1.200±0.00 2.679±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005XD CIL_0005XD_0002 CGP 12:95020229-95217482
CIL_0000Y0 CIL_0000Y0_0002 CGP 12:95076749-95302790

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001726 ISS ruffle
GO:0005085 ISS guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005737 ISS cytoplasm
GO:0005794 ISS Golgi apparatus
GO:0005856 IEA cytoskeleton
GO:0007010 ISS cytoskeleton organization
GO:0008360 ISS regulation of cell shape
GO:0030027 ISS lamellipodium
GO:0030036 ISS actin cytoskeleton organization
GO:0031267 ISS small GTPase binding
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0043088 ISS regulation of Cdc42 GTPase activity
GO:0043547 ISS positive regulation of GTPase activity
GO:0046847 ISS filopodium assembly
GO:0046872 IEA metal ion binding

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000020208 Fgd6-001 protein_coding Mus_musculus 0 2407
ENSMUST00000141143 Fgd6-002 processed_transcript Mus_musculus 0 220
ENSMUST00000125535 Fgd6-003 retained_intron Mus_musculus 4e-23 115

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