C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: FYVE, RhoGEF and PH domain containing 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000180263 FGD6 9606 - 12:95076749-95217482 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000343958 FGD6-001 95076749-95217464 protein_coding
  ENST00000451107 FGD6-003 95081398-95217482 nonsense_mediated_decay
  ENST00000546711 FGD6-004 95085543-95217464 protein_coding
  ENST00000548069 FGD6-006 95081170-95091787 protein_coding
  ENST00000549499 FGD6-002 95092828-95217379 protein_coding
  ENST00000550368 FGD6-007 95189192-95208956 processed_transcript
  ENST00000551521 FGD6-005 95091707-95116973 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000343958ENST00000451107ENST00000546711ENST00000549499
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000343958 0.399±0.00 0.124±0.00 N/A 0.540±0.13 N/A 0.864±0.14 0.633±0.22 0.366±0.14 0.751±0.55 1.781±0.32 0.256±0.06 0.975±0.72 0.412±0.13 1.025±0.00
ENST00000451107 N/A N/A N/A N/A 0.478±0.00 N/A N/A N/A N/A N/A 0.182±0.00 N/A N/A N/A
ENST00000546711 N/A 0.407±0.00 N/A 0.437±0.17 0.432±0.21 0.722±0.00 0.590±0.00 N/A 1.200±0.00 N/A N/A 2.679±0.00 N/A N/A
ENST00000549499 N/A N/A 1.448±0.00 0.994±0.00 4.443±0.00 2.940±0.00 0.363±0.00 0.909±0.00 N/A 3.003±0.00 N/A 1.240±0.33 N/A 0.903±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005XD CIL_0005XD_0002 CGP 12:95020229-95217482
CIL_0000Y0 CIL_0000Y0_0002 CGP 12:95076749-95302790

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001726 ISS ruffle
GO:0005085 ISS guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005737 ISS cytoplasm
GO:0005794 ISS Golgi apparatus
GO:0005856 IEA cytoskeleton
GO:0007010 ISS cytoskeleton organization
GO:0008360 ISS regulation of cell shape
GO:0030027 ISS lamellipodium
GO:0030036 ISS actin cytoskeleton organization
GO:0031267 ISS small GTPase binding
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0043088 ISS regulation of Cdc42 GTPase activity
GO:0043547 ISS positive regulation of GTPase activity
GO:0046847 ISS filopodium assembly
GO:0046872 IEA metal ion binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000045528 fgd6 FYVE, RhoGEF and PH domain containing 6 protein_coding Danio_rerio
ENSMUSG00000020021 Fgd6 FYVE, RhoGEF and PH domain containing 6 protein_coding Mus_musculus

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