C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: twist family bHLH transcription factor 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000612363 TWIST2-201 ENSG00000233608 9606 + 2:238848032-238910543 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000612363
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000612363 44.115±0.00 2.699±0.00 0.058±0.00 0.040±0.00 11.512±11.10 7.708±7.27 1.254±0.00 1.124±0.00 0.514±0.29 2.319±1.95 0.901±0.00 11.240±11.84 13.627±6.84 4.419±2.32

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003NF CIL_0003NF_0001 CGP 2:238426742-238910543
CIL_0007UT CIL_0007UT_0001 VISTA 2:238792799-239398211
CIL_0003NG CIL_0003NG_0001 CGP 2:238848032-239401654

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001076 IEA RNA polymerase II transcription factor binding transcription factor activity
GO:0001649 IEA osteoblast differentiation
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IEA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007275 IEA multicellular organismal development
GO:0008285 IEA negative regulation of cell proliferation
GO:0010838 IEA positive regulation of keratinocyte proliferation
GO:0019904 IEA protein domain specific binding
GO:0030154 IEA cell differentiation
GO:0032720 IEA negative regulation of tumor necrosis factor production
GO:0043066 IEA negative regulation of apoptotic process
GO:0043392 IEA negative regulation of DNA binding
GO:0044092 IEA negative regulation of molecular function
GO:0045638 IEA negative regulation of myeloid cell differentiation
GO:0045668 IDA negative regulation of osteoblast differentiation
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0046983 IEA protein dimerization activity
GO:0048701 IEA embryonic cranial skeleton morphogenesis
GO:0060325 IEA face morphogenesis
GO:0061303 IEA cornea development in camera-type eye

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000007949 Twist2-001 protein_coding Mus_musculus 0 1033
ENSMUST00000186075 Twist2-002 protein_coding Mus_musculus 0 1016
ENSMUST00000049089 Twist1-201 protein_coding Mus_musculus 0 390
ENSDART00000011146 twist3-201 protein_coding Danio_rerio 0 281

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