C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: twist basic helix-loop-helix transcription factor 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000049089 Twist1-201 ENSMUSG00000035799 10090 + 12:33957671-33959817 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000049089
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000049089 13.967±1.50 7.715±3.79 5.103±1.08 3.986±2.55 18.911±8.86 3.941±0.37 1.162±0.16 0.977±0.36 0.317±0.28 0.515±0.13 0.554±0.14 16.187±6.50 2.235±1.71 0.622±0.10

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00084F CIL_00084F_0002 VISTA 12:33655273-34257220
CIL_0008VF CIL_0008VF_0002 VISTA 12:33664466-34267804
CIL_0007LO CIL_0007LO_0002 UCNEbase 12:33675251-34394390
CIL_0008A9 CIL_0008A9_0002 VISTA 12:33899630-34500876
CIL_0008Z7 CIL_0008Z7_0002 VISTA 12:33915261-34516362
CIL_0008Z6 CIL_0008Z6_0002 VISTA 12:33919670-34521315

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000981 IEA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 TAS RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001503 IMP ossification
GO:0001649 IMP osteoblast differentiation
GO:0001701 IMP in utero embryonic development
GO:0001764 IMP neuron migration
GO:0001843 IMP neural tube closure
GO:0003180 IMP aortic valve morphogenesis
GO:0003183 IMP mitral valve morphogenesis
GO:0003203 IMP endocardial cushion morphogenesis
GO:0003253 IMP cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007517 IEA muscle organ development
GO:0008134 IPI transcription factor binding
GO:0010628 IEA positive regulation of gene expression
GO:0010718 IMP positive regulation of epithelial to mesenchymal transition
GO:0014067 IEA negative regulation of phosphatidylinositol 3-kinase signaling
GO:0019904 IPI protein domain specific binding
GO:0030154 IMP cell differentiation
GO:0030326 IMP embryonic limb morphogenesis
GO:0030500 IEA regulation of bone mineralization
GO:0032000 IEA positive regulation of fatty acid beta-oxidation
GO:0032720 IGI negative regulation of tumor necrosis factor production
GO:0032760 IEA positive regulation of tumor necrosis factor production
GO:0033128 IEA negative regulation of histone phosphorylation
GO:0035067 IDA negative regulation of histone acetylation
GO:0035115 IMP embryonic forelimb morphogenesis
GO:0035116 IMP embryonic hindlimb morphogenesis
GO:0035137 IMP hindlimb morphogenesis
GO:0035359 IDA negative regulation of peroxisome proliferator activated receptor signaling pathway
GO:0042476 IEA odontogenesis
GO:0042733 IMP embryonic digit morphogenesis
GO:0042803 IDA protein homodimerization activity
GO:0043066 IMP negative regulation of apoptotic process
GO:0043425 IEA bHLH transcription factor binding
GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043518 IEA negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044092 IDA negative regulation of molecular function
GO:0045596 IDA negative regulation of cell differentiation
GO:0045668 IDA negative regulation of osteoblast differentiation
GO:0045843 IDA negative regulation of striated muscle tissue development
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045944 TAS positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IDA protein heterodimerization activity
GO:0048511 IEA rhythmic process
GO:0048642 IDA negative regulation of skeletal muscle tissue development
GO:0048701 IGI embryonic cranial skeleton morphogenesis
GO:0048704 IMP embryonic skeletal system morphogenesis
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0060021 IEA palate development
GO:0060348 IEA bone development
GO:0060363 IMP cranial suture morphogenesis
GO:0060900 IEA embryonic camera-type eye formation
GO:0061029 IEA eyelid development in camera-type eye
GO:0061309 IMP cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0070888 TAS E-box binding
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071456 IMP cellular response to hypoxia
GO:0071639 IEA positive regulation of monocyte chemotactic protein-1 production
GO:2000147 IMP positive regulation of cell motility
GO:2000276 IDA negative regulation of oxidative phosphorylation uncoupler activity
GO:2000679 IEA positive regulation of transcription regulatory region DNA binding
GO:2000773 IEA negative regulation of cellular senescence
GO:2000778 IEA positive regulation of interleukin-6 secretion
GO:2000780 IEA negative regulation of double-strand break repair
GO:2000793 IMP cell proliferation involved in heart valve development
GO:2000802 IDA positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000011146 twist3-201 protein_coding Danio_rerio 0 327
ENST00000242261 TWIST1-001 protein_coding Homo_sapiens 0 1940
ENST00000354571 TWIST1-003 nonsense_mediated_decay Homo_sapiens 0 664
ENST00000443687 TWIST1-002 nonsense_mediated_decay Homo_sapiens 0 422
ENST00000448943 TWIST2-001 protein_coding Homo_sapiens 0 390
ENST00000612363 TWIST2-201 protein_coding Homo_sapiens 0 390

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