C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000008196 TFAP2B 9606 + 6:50818723-50847613 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000344788 TFAP2B-002 50818723-50828679 protein_coding
  ENST00000393655 TFAP2B-001 50818723-50847613 protein_coding
  ENST00000489228 TFAP2B-003 50821785-50823865 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainBreastHeartKidneyLiverMuscleOvaryPlacentaTestisENST00000344788ENST00000393655
Transcript ID Adipose Brain Breast Heart Kidney Liver Muscle Ovary Placenta Testis
ENST00000344788 0.026±0.00 N/A N/A N/A N/A N/A N/A 0.043±0.00 N/A N/A
ENST00000393655 0.006±0.00 0.005±0.00 0.426±0.00 0.004±0.00 2.578±0.00 0.025±0.02 0.011±0.00 0.019±0.01 0.237±0.00 0.758±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007MC CIL_0007MC_0001 UCNEbase 6:50093187-51124665
CIL_000813 CIL_000813_0001 VISTA 6:50284539-50886680
CIL_00096L CIL_00096L_0001 VISTA 6:50417531-51018524
CIL_0005MY CIL_0005MY_0001 CGP 6:50713828-50847613
CIL_00092G CIL_00092G_0001 VISTA 6:50808492-51409496
CIL_0005MX CIL_0005MX_0001 CGP 6:50818723-52087625

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000979 IDA RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981 IDA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0000983 ISS RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001105 ISS RNA polymerase II transcription coactivator activity
GO:0001106 ISS RNA polymerase II transcription corepressor activity
GO:0001158 IDA enhancer sequence-specific DNA binding
GO:0001822 ISS kidney development
GO:0003091 ISS renal water homeostasis
GO:0003677 TAS DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003713 IDA transcription coactivator activity
GO:0003714 IDA transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0006006 IMP glucose metabolic process
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007423 IEA sensory organ development
GO:0008284 IDA positive regulation of cell proliferation
GO:0008285 IDA negative regulation of cell proliferation
GO:0010226 IEA response to lithium ion
GO:0010842 IEP retina layer formation
GO:0010960 ISS magnesium ion homeostasis
GO:0030510 ISS regulation of BMP signaling pathway
GO:0035136 ISS forelimb morphogenesis
GO:0035137 ISS hindlimb morphogenesis
GO:0035810 ISS positive regulation of urine volume
GO:0035909 ISS aorta morphogenesis
GO:0042493 IEA response to drug
GO:0042593 ISS glucose homeostasis
GO:0042803 IPI protein homodimerization activity
GO:0043027 ISS cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 ISS negative regulation of apoptotic process
GO:0043154 ISS negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0043525 IDA positive regulation of neuron apoptotic process
GO:0043565 IDA sequence-specific DNA binding
GO:0043588 IEA skin development
GO:0045444 IEP fat cell differentiation
GO:0045595 IDA regulation of cell differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IPI protein heterodimerization activity
GO:0046983 IDA protein dimerization activity
GO:0048485 ISS sympathetic nervous system development
GO:0050796 IMP regulation of insulin secretion
GO:0055062 ISS phosphate ion homeostasis
GO:0055074 ISS calcium ion homeostasis
GO:0055075 ISS potassium ion homeostasis
GO:0055078 ISS sodium ion homeostasis
GO:0072017 ISS distal tubule development
GO:0072044 ISS collecting duct development
GO:0072210 IEA metanephric nephron development
GO:0097070 ISS ductus arteriosus closure
GO:0097275 ISS cellular ammonia homeostasis
GO:0097276 ISS cellular creatinine homeostasis
GO:0097277 ISS cellular urea homeostasis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012667 tfap2b transcription factor AP-2 beta protein_coding Danio_rerio
ENSMUSG00000025927 Tfap2b transcription factor AP-2 beta protein_coding Mus_musculus

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