C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein inhibitor of activated STAT, 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000033800 PIAS1 9606 + 15:68054179-68198603 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000249636 PIAS1-001 68054179-68193846 protein_coding
  ENST00000545237 PIAS1-002 68054576-68188064 protein_coding
  ENST00000562190 PIAS1-005 68054318-68142339 nonsense_mediated_decay
  ENST00000563996 PIAS1-003 68181211-68190758 nonsense_mediated_decay
  ENST00000564009 PIAS1-004 68146662-68153961 retained_intron
  ENST00000564915 PIAS1-007 68054309-68142339 nonsense_mediated_decay
  ENST00000567417 PIAS1-006 68176538-68181873 processed_transcript
  ENST00000611270 PIAS1-008 68191682-68198603 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainBreastHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000249636ENST00000545237ENST00000564915
Transcript ID Bladder Brain Breast Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000249636 N/A N/A 2.226±0.00 3.165±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000545237 2.873±0.00 6.995±0.00 N/A 4.154±1.04 4.264±0.00 5.523±3.55 6.373±0.74 2.468±0.73 5.584±1.26 3.785±0.13 9.692±0.83
ENST00000564915 N/A N/A N/A N/A N/A N/A N/A 3.136±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008DX CIL_0008DX_0001 VISTA 15:67486945-68088375
CIL_00098T CIL_00098T_0001 VISTA 15:67539824-68142788
CIL_0008FO CIL_0008FO_0001 VISTA 15:67583922-68185582
CIL_0004L4 CIL_0004L4_0002 CGP 15:67819704-68198603

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0003676 IEA nucleic acid binding
GO:0003677 IEA DNA binding
GO:0003713 NAS transcription coactivator activity
GO:0003714 TAS transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0007259 TAS JAK-STAT cascade
GO:0007283 IEA spermatogenesis
GO:0008152 IEA metabolic process
GO:0008270 IEA zinc ion binding
GO:0016605 ISS PML body
GO:0016925 ISS protein sumoylation
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019789 IDA SUMO ligase activity
GO:0019899 IPI enzyme binding
GO:0019904 IEA protein domain specific binding
GO:0030521 NAS androgen receptor signaling pathway
GO:0031625 IEA ubiquitin protein ligase binding
GO:0032436 ISS positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033235 IDA positive regulation of protein sumoylation
GO:0042127 ISS regulation of cell proliferation
GO:0045893 NAS positive regulation of transcription, DNA-templated
GO:0050681 NAS androgen receptor binding
GO:0051152 IEA positive regulation of smooth muscle cell differentiation
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0060334 TAS regulation of interferon-gamma-mediated signaling pathway
GO:0065004 IEA protein-DNA complex assembly

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000036094 PIAS1 (1 of 2) protein inhibitor of activated STAT, 1 protein_coding Danio_rerio
ENSDARG00000062445 pias1b protein inhibitor of activated STAT, 1b protein_coding Danio_rerio
ENSMUSG00000032405 Pias1 protein inhibitor of activated STAT 1 protein_coding Mus_musculus

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