C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tyrosyl-DNA phosphodiesterase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000042088 TDP1 9606 + 14:89954939-90044768 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000335725 TDP1-001 89955951-90044768 protein_coding
  ENST00000393452 TDP1-003 89955902-90043341 protein_coding
  ENST00000393454 TDP1-006 89955938-90043344 protein_coding
  ENST00000545686 TDP1-004 89956565-90043341 nonsense_mediated_decay
  ENST00000553527 TDP1-013 89956037-89963552 protein_coding
  ENST00000553569 TDP1-012 89956010-89957187 retained_intron
  ENST00000553617 TDP1-010 89955941-89984587 protein_coding
  ENST00000553989 TDP1-014 89956523-89963557 protein_coding
  ENST00000554180 TDP1-009 89955907-89980587 protein_coding
  ENST00000554976 TDP1-002 89954939-90043252 nonsense_mediated_decay
  ENST00000555178 TDP1-005 89956572-90043315 nonsense_mediated_decay
  ENST00000555565 TDP1-015 89955955-89980592 processed_transcript
  ENST00000555880 TDP1-007 89963105-90043309 protein_coding
  ENST00000556063 TDP1-008 89985159-90033616 protein_coding
  ENST00000556498 TDP1-017 89958293-89963599 protein_coding
  ENST00000556867 TDP1-011 89955993-89963569 protein_coding
  ENST00000557782 TDP1-016 89975781-89983205 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000335725ENST00000393452ENST00000393454ENST00000545686ENST00000553617ENST00000553989ENST00000554180ENST00000554976ENST00000555178ENST00000555880ENST00000556867
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000335725 1.180±0.00 1.677±0.00 N/A 0.778±0.01 0.376±0.00 0.347±0.17 0.053±0.00 0.143±0.00 N/A 0.646±0.00 N/A 0.935±0.31 N/A N/A
ENST00000393452 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.472±0.00 N/A
ENST00000393454 N/A 1.584±0.00 N/A N/A 0.857±0.23 N/A 0.143±0.00 1.518±0.00 0.406±0.00 0.815±0.24 0.418±0.00 0.745±0.14 1.578±0.65 N/A
ENST00000545686 N/A N/A N/A N/A N/A N/A N/A 0.290±0.00 N/A N/A N/A N/A N/A N/A
ENST00000553617 N/A N/A N/A N/A N/A 5.759±0.00 0.055±0.00 0.507±0.00 0.890±0.00 N/A 0.126±0.00 N/A N/A N/A
ENST00000553989 N/A N/A N/A N/A N/A 0.785±0.00 0.113±0.00 N/A 0.842±0.00 1.840±0.00 N/A 1.795±0.00 N/A N/A
ENST00000554180 N/A N/A N/A N/A N/A N/A 0.085±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000554976 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.751±0.00
ENST00000555178 0.743±0.00 N/A N/A 0.408±0.00 N/A 0.306±0.00 0.214±0.00 N/A 0.692±0.00 1.005±0.00 N/A N/A N/A 7.562±0.00
ENST00000555880 N/A N/A 0.283±0.00 N/A 1.008±0.00 N/A N/A 0.228±0.00 N/A N/A N/A N/A N/A N/A
ENST00000556867 N/A N/A 0.605±0.00 N/A N/A N/A N/A N/A 0.815±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005C6 CIL_0005C6_0001 CGP 14:89794669-90044768
CIL_0001TZ CIL_0001TZ_0001 CGP 14:89954939-90185857

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000012 IDA single strand break repair
GO:0003690 IDA double-stranded DNA binding
GO:0003697 IDA single-stranded DNA binding
GO:0004527 IEA exonuclease activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0006281 IDA:IEA DNA repair
GO:0006302 IDA double-strand break repair
GO:0008081 IEA phosphoric diester hydrolase activity
GO:0008219 IEA cell death
GO:0017005 IDA 3'-tyrosyl-DNA phosphodiesterase activity
GO:0090305 IEA nucleic acid phosphodiester bond hydrolysis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000073866 tdp1 tyrosyl-DNA phosphodiesterase 1 protein_coding Danio_rerio
ENSMUSG00000021177 Tdp1 tyrosyl-DNA phosphodiesterase 1 protein_coding Mus_musculus

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