C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cathepsin A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000064601 CTSA 9606 + 20:45890144-45898820 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000191018 CTSA-004 45891341-45898820 protein_coding
  ENST00000354880 CTSA-006 45891322-45898820 protein_coding
  ENST00000372459 CTSA-012 45891376-45898786 protein_coding
  ENST00000372484 CTSA-001 45891044-45898820 protein_coding
  ENST00000419493 CTSA-020 45892752-45895132 protein_coding
  ENST00000480961 CTSA-009 45893988-45895250 retained_intron
  ENST00000484855 CTSA-010 45896381-45898820 retained_intron
  ENST00000485627 CTSA-007 45892306-45894329 retained_intron
  ENST00000493522 CTSA-008 45892961-45897794 retained_intron
  ENST00000606000 CTSA-022 45897626-45898627 retained_intron
  ENST00000606066 CTSA-014 45891335-45892764 retained_intron
  ENST00000606394 CTSA-018 45891313-45893299 nonsense_mediated_decay
  ENST00000606782 CTSA-019 45892408-45893229 retained_intron
  ENST00000606788 CTSA-023 45890144-45898820 nonsense_mediated_decay
  ENST00000607187 CTSA-021 45896599-45897783 retained_intron
  ENST00000607212 CTSA-017 45891357-45892454 retained_intron
  ENST00000607482 CTSA-016 45891376-45892295 protein_coding
  ENST00000607814 CTSA-015 45891355-45892372 retained_intron
  ENST00000607841 CTSA-013 45891335-45892247 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000191018ENST00000354880ENST00000372459ENST00000372484ENST00000480961ENST00000493522
Transcript ID Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000191018 7.110±0.00 2.621±0.00 6.610±0.00 N/A 1.723±0.00 4.074±0.00 2.343±0.00 3.544±0.00 N/A 47.113±41.81 103.242±16.51 N/A
ENST00000354880 N/A 25.859±0.00 26.821±0.00 16.668±0.00 N/A N/A 16.503±0.00 N/A 2.884±0.00 N/A 79.138±0.00 11.214±0.00
ENST00000372459 N/A N/A 33.525±0.00 17.093±0.00 34.142±0.00 98.454±0.00 34.843±0.00 40.149±0.00 31.219±0.00 54.155±15.39 N/A N/A
ENST00000372484 N/A N/A N/A 4.042±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000480961 54.075±0.00 21.322±0.00 45.828±0.00 34.727±0.00 6.814±0.00 29.742±0.00 N/A 17.132±0.00 20.567±0.00 25.734±0.00 N/A N/A
ENST00000493522 15.311±0.00 7.605±0.00 N/A 7.631±0.00 N/A 5.339±0.00 N/A N/A N/A 10.811±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000RY CIL_0000RY_0001 CGP 20:45886489-45891287
CIL_0006GL CIL_0006GL_0001 CGP 20:45888625-45898820
CIL_0006IQ CIL_0006IQ_0002 CGP 20:45890144-45912155

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004180 TAS carboxypeptidase activity
GO:0004185 IEA serine-type carboxypeptidase activity
GO:0005515 IEA protein binding
GO:0005634 IDA nucleus
GO:0005739 IEA mitochondrion
GO:0005764 NAS lysosome
GO:0005783 TAS endoplasmic reticulum
GO:0006508 IEA proteolysis
GO:0006665 TAS sphingolipid metabolic process
GO:0006687 TAS glycosphingolipid metabolic process
GO:0006886 TAS intracellular protein transport
GO:0008047 TAS enzyme activator activity
GO:0016020 IDA membrane
GO:0043085 TAS positive regulation of catalytic activity
GO:0043202 TAS lysosomal lumen
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0044281 TAS small molecule metabolic process
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000078382 CTSA (1 of 2) cathepsin A protein_coding Danio_rerio
ENSDARG00000087307 ctsa cathepsin A protein_coding Danio_rerio
ENSMUSG00000017760 Ctsa cathepsin A protein_coding Mus_musculus

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