C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: fibroblast growth factor receptor 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000068078 FGFR3 9606 + 4:1793307-1808872 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000260795 FGFR3-001 1793833-1808871 protein_coding
  ENST00000340107 FGFR3-201 1793312-1808872 protein_coding
  ENST00000352904 FGFR3-002 1793896-1808871 protein_coding
  ENST00000412135 FGFR3-202 1793312-1808872 protein_coding
  ENST00000440486 FGFR3-203 1793312-1808872 protein_coding
  ENST00000469068 FGFR3-005 1804492-1805859 retained_intron
  ENST00000474521 FGFR3-004 1801629-1803152 processed_transcript
  ENST00000481110 FGFR3-006 1793307-1808865 protein_coding
  ENST00000507588 FGFR3-007 1801462-1803739 protein_coding
  ENST00000613647 FGFR3-204 1793312-1808872 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000260795ENST00000340107ENST00000352904ENST00000412135ENST00000440486ENST00000469068ENST00000474521ENST00000481110ENST00000613647
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000260795 N/A 0.656±0.00 0.971±0.00 24.377±17.28 N/A 0.415±0.00 N/A N/A N/A N/A N/A 0.256±0.00 3.960±1.21 10.740±4.80
ENST00000340107 0.142±0.00 N/A 0.915±0.00 N/A 0.436±0.00 0.347±0.00 0.085±0.00 2.353±0.07 3.042±2.72 1.866±1.47 N/A 1.619±1.47 N/A N/A
ENST00000352904 N/A N/A N/A N/A N/A 0.453±0.00 0.068±0.00 0.649±0.00 N/A N/A 0.106±0.01 0.947±0.47 3.705±0.00 2.270±0.00
ENST00000412135 N/A N/A N/A N/A N/A N/A N/A 0.476±0.00 N/A N/A N/A N/A N/A N/A
ENST00000440486 N/A N/A N/A N/A N/A N/A N/A 1.244±0.00 N/A N/A N/A N/A N/A N/A
ENST00000469068 N/A N/A N/A N/A N/A N/A 0.332±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000474521 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.985±0.00 N/A N/A
ENST00000481110 N/A 0.494±0.00 N/A 1.285±0.00 0.115±0.00 0.112±0.00 N/A N/A N/A 0.304±0.00 N/A N/A N/A N/A
ENST00000613647 N/A N/A N/A N/A N/A 0.171±0.00 N/A 1.221±0.00 N/A N/A N/A 0.163±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007TX CIL_0007TX_0001 VISTA 4:1311752-1912379
CIL_0006V2 CIL_0006V2_0001 CGP 4:1721490-1808872
CIL_0006V3 CIL_0006V3_0001 CGP 4:1793307-1856247

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000165 IEA MAPK cascade
GO:0001501 TAS skeletal system development
GO:0001938 IEA positive regulation of endothelial cell proliferation
GO:0001958 TAS endochondral ossification
GO:0002009 IEA morphogenesis of an epithelium
GO:0002062 TAS chondrocyte differentiation
GO:0002089 IEA lens morphogenesis in camera-type eye
GO:0003416 TAS endochondral bone growth
GO:0004672 IEA protein kinase activity
GO:0004713 IDA:IEA protein tyrosine kinase activity
GO:0005007 IMP:IEA fibroblast growth factor-activated receptor activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005576 IEA extracellular region
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005764 IEA lysosome
GO:0005783 IEA endoplasmic reticulum
GO:0005886 TAS plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0005925 TAS focal adhesion
GO:0006468 IEA protein phosphorylation
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007259 TAS JAK-STAT cascade
GO:0007267 IEA cell-cell signaling
GO:0008284 IMP:IEA positive regulation of cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 IDA:IEA fibroblast growth factor receptor signaling pathway
GO:0009898 IEA cytoplasmic side of plasma membrane
GO:0009986 IEA cell surface
GO:0010518 IMP positive regulation of phospholipase activity
GO:0014003 IEA oligodendrocyte development
GO:0016021 IEA integral component of membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017134 IPI fibroblast growth factor binding
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0021762 IEA substantia nigra development
GO:0022010 IEA central nervous system myelination
GO:0030154 IEA cell differentiation
GO:0030282 ISS bone mineralization
GO:0030900 IEA forebrain development
GO:0031398 IEA positive regulation of protein ubiquitination
GO:0031410 IEA cytoplasmic vesicle
GO:0035019 IEA somatic stem cell maintenance
GO:0035988 TAS chondrocyte proliferation
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042511 IMP positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 IMP positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043410 IMP positive regulation of MAPK cascade
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0043552 IMP positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 TAS innate immune response
GO:0045597 IEA positive regulation of cell differentiation
GO:0045839 IEA negative regulation of mitosis
GO:0045879 IEA negative regulation of smoothened signaling pathway
GO:0046777 IDA protein autophosphorylation
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048546 IEA digestive tract morphogenesis
GO:0048640 ISS negative regulation of developmental growth
GO:0048678 IEA response to axon injury
GO:0048712 IEA negative regulation of astrocyte differentiation
GO:0048839 IEA inner ear development
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0051216 IEA cartilage development
GO:0060113 IEA inner ear receptor cell differentiation
GO:0060349 TAS bone morphogenesis
GO:0060385 IEA axonogenesis involved in innervation
GO:0061144 IEA alveolar secondary septum development
GO:0070307 IEA lens fiber cell development
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0070977 ISS bone maturation
GO:0072148 IEA epithelial cell fate commitment
GO:0090080 IEA positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0090102 IEA cochlea development
GO:0090263 IEA positive regulation of canonical Wnt signaling pathway
GO:1902178 IMP fibroblast growth factor receptor apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004782 fgfr3 fibroblast growth factor receptor 3 protein_coding Danio_rerio
ENSMUSG00000054252 Fgfr3 fibroblast growth factor receptor 3 protein_coding Mus_musculus

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