C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: fibroblast growth factor receptor 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000054252 Fgfr3 10090 + 5:33721724-33737068 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000067150 Fgfr3-001 33721724-33737067 protein_coding
  ENSMUST00000087820 Fgfr3-002 33722398-33735607 protein_coding
  ENSMUST00000114411 Fgfr3-201 33721724-33737068 protein_coding
  ENSMUST00000132724 Fgfr3-006 33729964-33733283 retained_intron
  ENSMUST00000134610 Fgfr3-003 33723004-33732790 retained_intron
  ENSMUST00000142860 Fgfr3-004 33734605-33735564 retained_intron
  ENSMUST00000152661 Fgfr3-005 33733692-33734913 retained_intron
  ENSMUST00000155002 Fgfr3-007 33723772-33729850 protein_coding
  ENSMUST00000164207 Fgfr3-008 33721791-33737063 protein_coding
  ENSMUST00000169212 Fgfr3-202 33721724-33737068 protein_coding
  ENSMUST00000171509 Fgfr3-203 33722306-33737068 protein_coding
  ENSMUST00000181298 Fgfr3-009 33729738-33732743 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000067150ENSMUST00000087820ENSMUST00000114411ENSMUST00000134610ENSMUST00000152661ENSMUST00000164207ENSMUST00000169212ENSMUST00000171509
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000067150 0.607±0.00 0.803±0.32 N/A 10.044±4.77 0.688±0.00 N/A 1.334±0.29 4.608±0.00 1.158±0.23 N/A 0.241±0.00 1.737±0.18 N/A 0.542±0.15
ENSMUST00000087820 1.281±0.00 N/A N/A N/A N/A N/A 0.903±0.00 N/A N/A N/A 0.343±0.00 1.330±0.00 N/A 0.485±0.00
ENSMUST00000114411 N/A N/A 6.979±1.68 N/A N/A 7.476±2.16 N/A N/A 2.124±0.00 N/A N/A 1.312±0.00 0.973±0.00 N/A
ENSMUST00000134610 N/A 0.298±0.01 N/A N/A 0.758±0.29 6.591±1.31 1.200±0.00 6.404±1.43 1.888±1.47 29.163±0.16 0.189±0.00 2.084±0.68 N/A 0.438±0.00
ENSMUST00000152661 N/A N/A N/A 100.571±0.00 N/A N/A N/A N/A N/A N/A N/A 9.942±0.00 3.251±0.34 1.633±0.00
ENSMUST00000164207 1.952±0.53 0.590±0.29 N/A 6.534±0.79 1.201±0.37 4.293±0.57 0.728±0.16 7.062±1.73 1.145±0.96 32.732±4.27 0.230±0.00 2.315±1.19 1.234±0.60 0.929±0.00
ENSMUST00000169212 N/A N/A N/A 2.443±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.583±0.11
ENSMUST00000171509 0.554±0.00 N/A 5.211±2.06 9.536±0.00 2.126±0.30 12.917±1.53 0.481±0.00 7.385±2.58 4.854±3.72 26.388±1.34 0.237±0.03 1.602±0.50 1.932±1.02 0.080±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007TX CIL_0007TX_0002 VISTA 5:33275293-33875875
CIL_0006V2 CIL_0006V2_0002 CGP 5:33658128-33737068
CIL_0006V3 CIL_0006V3_0002 CGP 5:33721724-33782817

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000165 IDA MAPK cascade
GO:0001938 IMP positive regulation of endothelial cell proliferation
GO:0002009 IMP morphogenesis of an epithelium
GO:0002089 IMP lens morphogenesis in camera-type eye
GO:0005007 IDA fibroblast growth factor-activated receptor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005764 IDA lysosome
GO:0005887 IEA integral component of plasma membrane
GO:0007267 IEA cell-cell signaling
GO:0008284 IGI positive regulation of cell proliferation
GO:0008285 IMP negative regulation of cell proliferation
GO:0008543 IDA fibroblast growth factor receptor signaling pathway
GO:0009898 IDA cytoplasmic side of plasma membrane
GO:0009986 IEA cell surface
GO:0010518 IEA positive regulation of phospholipase activity
GO:0014003 IMP oligodendrocyte development
GO:0016021 IEA integral component of membrane
GO:0017134 IEA fibroblast growth factor binding
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0021762 IMP substantia nigra development
GO:0022010 IMP central nervous system myelination
GO:0030154 IMP cell differentiation
GO:0030900 IMP forebrain development
GO:0031398 IDA positive regulation of protein ubiquitination
GO:0035019 IMP somatic stem cell maintenance
GO:0042511 IEA positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 IEA positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043410 IMP positive regulation of MAPK cascade
GO:0043525 IMP positive regulation of neuron apoptotic process
GO:0043552 IEA positive regulation of phosphatidylinositol 3-kinase activity
GO:0045597 IMP positive regulation of cell differentiation
GO:0045839 IGI negative regulation of mitosis
GO:0045879 IMP negative regulation of smoothened signaling pathway
GO:0046777 IEA protein autophosphorylation
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048546 IMP digestive tract morphogenesis
GO:0048678 IMP response to axon injury
GO:0048712 IMP negative regulation of astrocyte differentiation
GO:0048839 IMP inner ear development
GO:0050680 IMP negative regulation of epithelial cell proliferation
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0051216 IMP cartilage development
GO:0060113 IMP inner ear receptor cell differentiation
GO:0060349 IMP bone morphogenesis
GO:0060385 IMP axonogenesis involved in innervation
GO:0061144 IGI alveolar secondary septum development
GO:0070307 IGI lens fiber cell development
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0072148 IMP epithelial cell fate commitment
GO:0090080 IGI positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0090102 IMP cochlea development
GO:0090263 IMP positive regulation of canonical Wnt signaling pathway
GO:1902178 IEA fibroblast growth factor receptor apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004782 fgfr3 fibroblast growth factor receptor 3 protein_coding Danio_rerio
ENSG00000068078 FGFR3 fibroblast growth factor receptor 3 protein_coding Homo_sapiens

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