C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: fibroblast activation protein, alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000078098 FAP 9606 - 2:162170684-162245151 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000188790 FAP-001 162170690-162243535 protein_coding
  ENST00000422436 FAP-004 162170684-162198826 nonsense_mediated_decay
  ENST00000443424 FAP-015 162170718-162243456 protein_coding
  ENST00000447386 FAP-007 162219142-162243048 protein_coding
  ENST00000450031 FAP-012 162219857-162243102 nonsense_mediated_decay
  ENST00000461506 FAP-010 162172841-162183583 retained_intron
  ENST00000462608 FAP-014 162170684-162173781 nonsense_mediated_decay
  ENST00000465088 FAP-011 162198624-162203145 retained_intron
  ENST00000465424 FAP-008 162193559-162198842 retained_intron
  ENST00000480044 FAP-005 162170685-162176669 retained_intron
  ENST00000480838 FAP-003 162209620-162243413 retained_intron
  ENST00000493182 FAP-006 162243347-162245151 processed_transcript
  ENST00000497414 FAP-009 162188172-162195037 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000188790ENST00000422436ENST00000443424ENST00000447386ENST00000461506ENST00000462608ENST00000465088ENST00000480044ENST00000480838ENST00000497414
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000188790 2.507±0.00 N/A N/A N/A 4.183±2.57 0.963±0.76 0.140±0.00 0.475±0.00 N/A 1.015±0.00 N/A 0.968±0.48 2.628±0.08 2.038±0.00
ENST00000422436 1.290±0.00 0.571±0.00 N/A 0.355±0.00 1.455±0.00 N/A N/A N/A 0.064±0.00 N/A 0.810±0.00 0.834±0.03 N/A 1.325±0.00
ENST00000443424 N/A N/A N/A 0.142±0.00 N/A 0.174±0.00 0.177±0.00 N/A 0.451±0.00 0.524±0.29 N/A 1.144±0.00 2.183±0.77 N/A
ENST00000447386 N/A N/A 0.127±0.00 N/A N/A N/A N/A 0.106±0.00 0.061±0.00 0.919±0.00 N/A N/A N/A 1.041±0.00
ENST00000461506 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.557±0.00 5.485±0.00 N/A 1.538±0.00
ENST00000462608 N/A N/A N/A N/A N/A N/A N/A N/A 0.052±0.00 N/A N/A N/A N/A 1.097±0.00
ENST00000465088 N/A N/A 0.695±0.00 N/A N/A N/A N/A N/A 0.129±0.00 N/A 1.322±0.00 N/A N/A N/A
ENST00000480044 N/A N/A N/A N/A N/A N/A 0.165±0.00 N/A 0.021±0.00 N/A N/A N/A N/A N/A
ENST00000480838 N/A N/A N/A 0.149±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000497414 N/A N/A N/A N/A N/A N/A 0.200±0.00 N/A N/A N/A 0.826±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003S0 CIL_0003S0_0002 CGP 2:162142873-162245151
CIL_0005KX CIL_0005KX_0001 CGP 2:162170684-162318703

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002020 IPI protease binding
GO:0004175 IDA endopeptidase activity
GO:0004222 TAS metalloendopeptidase activity
GO:0004252 IDA serine-type endopeptidase activity
GO:0005178 IPI integrin binding
GO:0005515 IPI protein binding
GO:0005615 IDA extracellular space
GO:0005886 NAS plasma membrane
GO:0005925 IDA focal adhesion
GO:0006508 IEA:IDA proteolysis
GO:0008233 IDA peptidase activity
GO:0008236 IDA:IEA serine-type peptidase activity
GO:0008239 IDA dipeptidyl-peptidase activity
GO:0009986 ISS cell surface
GO:0010710 IDA regulation of collagen catabolic process
GO:0010716 IDA negative regulation of extracellular matrix disassembly
GO:0016020 IEA membrane
GO:0016021 NAS integral component of membrane
GO:0030027 IDA lamellipodium
GO:0032587 NAS ruffle membrane
GO:0042803 IDA protein homodimerization activity
GO:0043542 IDA endothelial cell migration
GO:0045177 IEA apical part of cell
GO:0045178 IEA basal part of cell
GO:0046983 NAS protein dimerization activity
GO:0051603 IDA proteolysis involved in cellular protein catabolic process
GO:0051917 IC regulation of fibrinolysis
GO:0060244 ISS negative regulation of cell proliferation involved in contact inhibition
GO:0071158 ISS positive regulation of cell cycle arrest
GO:0071438 IDA invadopodium membrane
GO:0071850 ISS mitotic cell cycle arrest
GO:0097325 ISS melanocyte proliferation
GO:1900119 ISS positive regulation of execution phase of apoptosis
GO:1902362 ISS melanocyte apoptotic process
GO:1903054 IDA negative regulation of extracellular matrix organization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000078468 fap fibroblast activation protein, alpha protein_coding Danio_rerio
ENSDARG00000079420 dpp4 dipeptidyl-peptidase 4 protein_coding Danio_rerio
ENSMUSG00000000392 Fap fibroblast activation protein protein_coding Mus_musculus

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